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Synthesis, characterization and in vitro antitumor activity of di- and triorganotin derivatives of polyoxa- and biologically relevant carboxylic acids.
An overview of the development of anti-tumor organotin derivatives, sometimes as active in vitro as doxorubicin, is presented and discussed and several water-soluble organotin compounds gave the best in vitro activities. Expand
Identification of mebeverine acid as the main circulating metabolite of mebeverine in man.
A reversed-phase HPLC method with coulometric detection was developed in order to assay the hitherto unidentified secondary metabolite mebeverine acid, which appears to be a valuable marker of oral exposure to meb Beverine. Expand
Strong differences in the in vitro cytotoxicity of three isomeric dichlorobis(2-phenylazopyridine)ruthenium(II) complexes.
The three isomeric dichlororuthenium(II) complexes α-, β-, and γ-[Ru(azpy)2Cl2] (azpy = 2-phenylazopyridine) have been investigated for their cytotoxic properties against a series of tumor-cellExpand
Cytotoxicity, qualitative structure-activity relationship (QSAR), and anti-tumor activity of bismuth dithiocarbamate complexes.
Bismuth dithiocarbamate complexes of general formula Bi(S(2)CNR(2))(3) demonstrate potent in vitro cytotoxicity against a panel of seven human cancer cell lines; a structure-activity relationship hasExpand
Cytotoxicity Profiles for a Series of Triorganophosphinegold(I) Dithiocarbamates and Triorganophosphinegold(I) Xanthates
The dithiocarbamate derivatives are more active than their xanthate counterparts, with the most active complex being Et3PAu(S2CNEt2), and are moreactive than cisplatin in all cell lines screened but, not as potent as taxol. Expand
Characterisation and In Vitro Cytotoxicity of Triorganophosphinegold(I) 2-Mercaptobenzoate Complexes
The preparation and full NMR characterisation of three [R3PAu(2mba] complexes are reported, which display moderate to very high activity against the H226 cell line (non-small cell lung cancer) compared with that displayed by a range of cytotoxic drugs. Expand
Synthesis, crystal structures, cytotoxicity and qualitative structure-activity relationship (QSAR) of cis-bis{5-[(E)-2-(aryl)-1-diazenyl]quinolinolato}di-n-butyltin(IV) complexes, (n)Bu2Sn(L)2.
The in vitro cytotoxicity of di-n-butyltin(IV) complexes (3-8) is reported against seven well characterized human tumour cell lines and the basicity of the two quinolinolato donor N and O atoms of the ligands are discussed in relation to the cytot toxicity data. Expand
Tridemethylisovelleral, a potent cytotoxic agent.
The synthesis and in vitro cytotoxicity toward various tumor cell lines of (+/-)-tridemethylisovelleral, an analogue of the bioactive fungal sesquiterpene (+)-isovelleral retaining theExpand
Synthesis, Characterization and Antitumour Activities of Di-n-Butyl- and Dimethyltin D-(+)-Camphorates
The synthesis and characterization of two novel diorganotin dicarboxylates, di-n-butyland dimethyltin D-(+)-camphorates, are reported in order to further investigate the influence of the structure of such a dicARboxylate moiety on antitumour properties7. Expand
Determination of tamoxifen and five metabolites in plasma.
The method was used to determine plasma levels of four further metabolites of tamoxifen from patients at steady state taking 30 mg TX daily and also in a study of patients taking a loading dose of TX before taking 30mg daily. Expand