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The decrease of fibrinogen is an early predictor of the severity of postpartum hemorrhage
- B. Charbit, L. Mandelbrot, D. de Prost
- MedicineJournal of thrombosis and haemostasis : JTH
- 1 February 2007
Findings indicate that a simple fibrinogen measurement can anticipate the risk of severe bleeding in PPH.
Elevated Cyclic AMP Inhibits NF-κB-mediated Transcription in Human Monocytic Cells and Endothelial Cells*
- V. Ollivier, G. Parry, R. Cobb, D. de Prost, N. Mackman
- Biology, ChemistryThe Journal of Biological Chemistry
- 23 August 1996
It is indicated that activation of PKA reduces the induction of a distinct set of genes in monocytes and endothelial cells by inhibiting NF-κB-mediated transcription.
Inflammatory, hemostatic, and clinical changes in a baboon experimental model for heatstroke.
The baboon model of heatstroke appears suitable for testing whether immunomodulation of the host's responses can improve outcome, and nonsurvivors displayed significantly greater coagulopathy, inflammatory activity, and tissue injury than survivors.
Activation of coagulation and fibrinolysis in heatstroke.
Cooling seems to attenuate the activation of fibrinolysis only, however, this requires confirmation in a larger study population, and Activation of coagulation and fibrin monomers occurs early and is profound and sustained in heatstroke.
Polymorphism in the fractalkine receptor CX3CR1 as a genetic risk factor for coronary artery disease.
Functional analysis of peripheral blood mononuclear cells showed that CX3CR1 I249 heterozygosity was associated with a significant decrease in the number of fractalkine binding sites per cell, showing that Cx3 CR1 may be involved in the pathogenesis of atherosclerotic disease.
Cardiovascular and Thromboembolic Risk Factors in Idiopathic Sudden Sensorineural Hearing Loss: A Case-Control Study
The theory of vascular involvement as the etiology of some cases of ISSHL is supported, and the sole predictive factor of poor final hearing is the severity of the initial hearing loss.
EXPERIMENTAL HEATSTROKE IN BABOON: ANALYSIS OF THE SYSTEMIC INFLAMMATORY RESPONSE
Results show that heatstroke activates complex systemic inflammatory and regulatory responses associated with outcome, and further definition of this ambivalent response is needed before identification of target of successful modulation may become possible.
Association of the Toll-Like Receptor 4 Gene Asp299Gly Polymorphism With Acute Coronary Events
- N. Ameziane, T. Beillat, D. de Prost
- Biology, MedicineArteriosclerosis, thrombosis, and vascular…
- 1 December 2003
Evidence of an association between the Asp299Gly polymorphism of the human TLR4 receptor and acute coronary syndromes is provided, which confirms the previously reported involvement of TLR 4 in carotid and femoral artery atherosclerosis.
Tissue factor-dependent vascular endothelial growth factor production by human fibroblasts in response to activated factor VII.
TF is essential for VIIa-induced VEGF production by human fibroblasts and that its role is mainly linked to the proteolytic activity of the TF-VIIa complex, as shown by the inhibitory effects of genistein and GF 109203X.
Vascular endothelial growth factor production by fibroblasts in response to factor VIIa binding to tissue factor involves thrombin and factor Xa.
- V. Ollivier, J. Chabbat, J. Herbert, J. Hakim, D. de Prost
- BiologyArteriosclerosis, thrombosis, and vascular…
- 1 May 2000
These findings indicate that F VIIa protease induction of VEGF expression is mediated by thrombin and FXa generated in response to FVIIa binding to TF-expressing fibroblasts; they exclude a direct signaling involving MAP kinase activation via the intracellular domain of TF when expressed by these cells.