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Equisetin and a novel opposite stereochemical homolog phomasetin, two fungal metabolites as inhibitors of HIV-1 integrase
Structure and chemistry of apicidins, a class of novel cyclic tetrapeptides without a terminal alpha-keto epoxide as inhibitors of histone deacetylase with potent antiprotozoal activities.
The isolation and structure elucidation of new apicidins from two Fusarium species, temperature-dependent NMR studies of apicIDin, NMR and molecular modeling based conformation of the 12-membered macrocyclic ring, and selected chemical modifications of Apicidin have been detailed in this paper.
Isolation and structure of platencin: a FabH and FabF dual inhibitor with potent broad-spectrum antibiotic activity.
Resorcylic acid lactones: naturally occurring potent and selective inhibitors of MEK.
A resorcylic acid lactone, L-783,277, isolated from a Phoma sp. (ATCC 74403) which came from the fruitbody of Helvella acetabulum, is a potent and specific inhibitor of MEK (Map kinase kinase).…
Flavones from Struthiola argentea with anthelmintic activity in vitro.
Durhamycin A, a potent inhibitor of HIV Tat transactivation.
Durhamycin A was discovered as a potent inhibitor (IC(50) = 4.8 nM) of Tat transactivation of HIV transactivation in efforts to discover Tat inhibitors from natural product screening of microbial fermentation extracts.
Distribution of the antifungal agents sordarins across filamentous fungi.
Isolation and structure elucidation of viridiofungins A, B and C
Isolation, structure, and absolute stereochemistry of platensimycin, a broad spectrum antibiotic discovered using an antisense differential sensitivity strategy.
- Sheo B. Singh, H. Jayasuriya, Jun Wang
- Chemistry, BiologyJournal of the American Chemical Society
- 19 August 2006
It was determined that potential reactivity of the enone moiety does not play a key role in the biological activity of platensimycin and cyclohexenone ring conformation renders for the stronger binding interaction with the enzyme.