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The first international consensus on mucous membrane pemphigoid: definition, diagnostic criteria, pathogenic factors, medical treatment, and prognostic indicators.
OBJECTIVE We aimed to develop consensus-based recommendations for streamlining medical communication among various health care professionals, to improve accuracy of diagnosis and treatment, and toExpand
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Pemphigoid diseases
Pemphigoid diseases are a group of well defined autoimmune disorders that are characterised by autoantibodies against structural proteins of the dermal-epidermal junction and, clinically, by tenseExpand
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The clinical phenotype of pemphigus is defined by the anti-desmoglein autoantibody profile.
BACKGROUND Some patients with pemphigus vulgaris (PV) have mucous membrane erosions with minimal skin involvement (mucosal dominant type), and others show extensive skin blisters and erosions inExpand
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Modern diagnosis of autoimmune blistering skin diseases.
The diagnostic gold standard of autoimmune bullous diseases is the detection of autoantibodies in skin or mucous membranes by direct immunofluorescence microscopy of a perilesional biopsy. TheExpand
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The Pathophysiology of Bullous Pemphigoid
Bullous pemphigoid (BP) is a blistering skin disease characterized by an autoimmune response to 2 hemidesmosomal proteins within the dermal–epidermal junction, designated BP180 and BP230. While BP230Expand
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Prospective analysis of the incidence of autoimmune bullous disorders in Lower Franconia, Germany
Background: Only limited epidemiologic data are available on autoimmune bullous diseases. Improved diagnostic tools should have led to an increased incidence. To test this hypothesis, all patientsExpand
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Inhibition of Rho A activity causes pemphigus skin blistering
The autoimmune blistering skin diseases pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are mainly caused by autoantibodies against desmosomal cadherins. In this study, we provide evidence thatExpand
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PI3Kβ Plays a Critical Role in Neutrophil Activation by Immune Complexes
The β isoform of phosphoinositide 3-kinase may be an effective therapeutic target in inflammatory diseases. The Integrating Isoform The class I phosphoinositide 3-kinases (PI3Ks) are implicated inExpand
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Tight clustering of extracellular BP180 epitopes recognized by bullous pemphigoid autoantibodies.
Bullous pemphigoid is a blistering skin disease associated with autoantibodies against the BP180 antigen, a transmembrane component of the hemidesmosome. Anti-BP180 antibodies have been demonstratedExpand
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Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcγRIIB and dectin-1
Complement is an ancient danger-sensing system that contributes to host defense, immune surveillance and homeostasis. C5a and its G protein–coupled receptor mediate many of the proinflammatoryExpand
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