Author pages are created from data sourced from our academic publisher partnerships and public sources.
The first international consensus on mucous membrane pemphigoid: definition, diagnostic criteria, pathogenic factors, medical treatment, and prognostic indicators.
OBJECTIVE We aimed to develop consensus-based recommendations for streamlining medical communication among various health care professionals, to improve accuracy of diagnosis and treatment, and to… Expand
Pemphigoid diseases are a group of well defined autoimmune disorders that are characterised by autoantibodies against structural proteins of the dermal-epidermal junction and, clinically, by tense… Expand
The clinical phenotype of pemphigus is defined by the anti-desmoglein autoantibody profile.
- M. Amagai, K. Tsunoda, D. Zillikens, T. Nagai, T. Nishikawa
- Journal of the American Academy of Dermatology
- 1 February 1999
BACKGROUND Some patients with pemphigus vulgaris (PV) have mucous membrane erosions with minimal skin involvement (mucosal dominant type), and others show extensive skin blisters and erosions in… Expand
Modern diagnosis of autoimmune blistering skin diseases.
The diagnostic gold standard of autoimmune bullous diseases is the detection of autoantibodies in skin or mucous membranes by direct immunofluorescence microscopy of a perilesional biopsy. The… Expand
The Pathophysiology of Bullous Pemphigoid
Bullous pemphigoid (BP) is a blistering skin disease characterized by an autoimmune response to 2 hemidesmosomal proteins within the dermal–epidermal junction, designated BP180 and BP230. While BP230… Expand
Prospective analysis of the incidence of autoimmune bullous disorders in Lower Franconia, Germany
- Franziska Bertram, E. Bröcker, D. Zillikens, E. Schmidt
- Journal der Deutschen Dermatologischen…
- 1 May 2009
Background: Only limited epidemiologic data are available on autoimmune bullous diseases. Improved diagnostic tools should have led to an increased incidence. To test this hypothesis, all patients… Expand
Inhibition of Rho A activity causes pemphigus skin blistering
- J. Waschke, V. Spindler, P. Bruggeman, D. Zillikens, G. Schmidt, D. Drenckhahn
- Medicine, Biology
- The Journal of cell biology
- 4 December 2006
The autoimmune blistering skin diseases pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are mainly caused by autoantibodies against desmosomal cadherins. In this study, we provide evidence that… Expand
PI3Kβ Plays a Critical Role in Neutrophil Activation by Immune Complexes
The β isoform of phosphoinositide 3-kinase may be an effective therapeutic target in inflammatory diseases. The Integrating Isoform The class I phosphoinositide 3-kinases (PI3Ks) are implicated in… Expand
Tight clustering of extracellular BP180 epitopes recognized by bullous pemphigoid autoantibodies.
- D. Zillikens, P. Rose, +4 authors George J. Giudice
- Biology, Medicine
- The Journal of investigative dermatology
- 1 October 1997
Bullous pemphigoid is a blistering skin disease associated with autoantibodies against the BP180 antigen, a transmembrane component of the hemidesmosome. Anti-BP180 antibodies have been demonstrated… Expand
Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcγRIIB and dectin-1
Complement is an ancient danger-sensing system that contributes to host defense, immune surveillance and homeostasis. C5a and its G protein–coupled receptor mediate many of the proinflammatory… Expand