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Epigenome-wide association study (EWAS) of BMI, BMI change and waist circumference in African American adults identifies multiple replicated loci.
Obesity is an important component of the pathophysiology of chronic diseases. Identifying epigenetic modifications associated with elevated adiposity, including DNA methylation variation, may pointExpand
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The Bioenergetic Health Index: a new concept in mitochondrial translational research
Bioenergetics has become central to our understanding of pathological mechanisms, the development of new therapeutic strategies and as a biomarker for disease progression in neurodegeneration,Expand
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Association of Body Mass Index with DNA Methylation and Gene Expression in Blood Cells and Relations to Cardiometabolic Disease: A Mendelian Randomization Approach
Background The link between DNA methylation, obesity, and adiposity-related diseases in the general population remains uncertain. Methods and Findings We conducted an association study of body massExpand
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Epigenome-Wide Association Study of Fasting Measures of Glucose, Insulin, and HOMA-IR in the Genetics of Lipid Lowering Drugs and Diet Network Study
Known genetic susceptibility loci for type 2 diabetes (T2D) explain only a small proportion of heritable T2D risk. We hypothesize that DNA methylation patterns may contribute to variation inExpand
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A Genome-Wide Association Study Identifies Multiple Regions Associated with Head Size in Catfish
Skull morphology is fundamental to evolution and the biological adaptation of species to their environments. With aquaculture fish species, head size is also important for economic reasons because itExpand
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Epigenome-wide study identifies novel methylation loci associated with body mass index and waist circumference
To conduct an epigenome‐wide analysis of DNA methylation and obesity traits.
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A genome-wide association study in catfish reveals the presence of functional hubs of related genes within QTLs for columnaris disease resistance
BackgroundColumnaris causes severe mortalities among many different wild and cultured freshwater fish species, but understanding of host resistance is lacking. Catfish, the primary aquacultureExpand
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Metabolic and inflammatory biomarkers are associated with epigenetic aging acceleration estimates in the GOLDN study
BackgroundRecently, epigenetic age acceleration—or older epigenetic age in comparison to chronological age—has been robustly associated with mortality and various morbidities. However, acceleratedExpand
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Identification of donor microbe species that colonize and persist long term in the recipient after fecal transplant for recurrent Clostridium difficile
Fecal microbiota transplantation has been shown to be an effective treatment for patients with recurrent C. difficile colitis. Although fecal microbiota transplantation helps to re-establish a normalExpand
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Epigenome-Wide Association Study of Fasting Blood Lipids in the Genetics of Lipid-Lowering Drugs and Diet Network Study
Background— Genetic research regarding blood lipids has largely focused on DNA sequence variation; few studies have explored epigenetic effects. Genome-wide surveys of DNA methylation may uncoverExpand
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