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Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6
Epigenetic modifiers have fundamental roles in defining unique cellular identity through the establishment and maintenance of lineage-specific chromatin and methylation status. Several DNA… Expand
Methyltransferase Dnmt3a upregulates HDAC9 to deacetylate the kinase TBK1 for activation of antiviral innate immunity
The DNA methyltransferase Dnmt3a has high expression in terminally differentiated macrophages; however, its role in innate immunity remains unknown. Here we report that deficiency in Dnmt3a… Expand
Characterization and comparative analyses of zebrafish intelectins: highly conserved sequences, diversified structures and functions.
Intelectin family, also called the X-lectin family, is a newly discovered gene family involved in development and innate immunity. However, no research was carried out for this gene family in the… Expand
The lectin Siglec-G inhibits dendritic cell cross-presentation by impairing MHC class I–peptide complex formation
CD8α+ dendritic cells (DCs) are specialized at cross-presenting extracellular antigens on major histocompatibility complex (MHC) class I molecules to initiate cytotoxic T lymphocyte (CTL) responses;… Expand
Histone Lysine Methyltransferase Ezh1 Promotes TLR-Triggered Inflammatory Cytokine Production by Suppressing Tollip
Histone modifications play critical roles in the regulation of gene expression; however, their roles in the regulation of the innate response remain to be fully investigated. Using transcriptome… Expand
Cytoplasmic STAT4 Promotes Antiviral Type I IFN Production by Blocking CHIP-Mediated Degradation of RIG-I
Retinoic acid–inducible gene I (RIG-I) signaling is critical to host innate immune response against RNA virus infection. Numerous factors use different mechanisms to regulate RIG-I signaling. In this… Expand
Death Domain-associated Protein 6 (Daxx) Selectively Represses IL-6 Transcription through Histone Deacetylase 1 (HDAC1)-mediated Histone Deacetylation in Macrophages*
- Z. Yao, Q. Zhang, +8 authors X. Cao
- Biology, Medicine
- The Journal of Biological Chemistry
- 18 February 2014
Background: The role and underlying mechanism of Daxx in innate immunity remain to be investigated. Results: Daxx interacts with HDAC1 and binds to the promoter of IL-6. Daxx selectively represses… Expand
Title Methyltransferase Dnmt 3 a upregulates HDAC 9 to deacetylate the kinase TBK 1 for activation of antiviral innate immunity
Bromodomain protein Brd3 promotes Ifnb1 transcription via enhancing IRF3/p300 complex formation and recruitment to Ifnb1 promoter in macrophages
As members of bromodomain and extra-terminal motif protein family, bromodomain-containing proteins regulate a wide range of biological processes including protein scaffolding, mitosis, cell cycle… Expand
H3K4me3 Demethylase Kdm5a Is Required for NK Cell Activation by Associating with p50 to Suppress SOCS1.
The H3K4me3 demethylase Kdm5a regulates gene transcription and is implicated in carcinogenesis. However, the role of Kdm5a in innate immune response remains poorly understood. Here, we demonstrate… Expand