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SIRT3 reverses aging-associated degeneration.
Despite recent controversy about their function in some organisms, sirtuins are thought to play evolutionarily conserved roles in lifespan extension. Whether sirtuins can reverse aging-associated… Expand
Microanatomy of Axon/Glial Signaling during Wallerian Degeneration
- Amy D Guertin, D. Zhang, K. Mak, J. Alberta, H. Kim
- Biology, Medicine
- The Journal of Neuroscience
- 30 March 2005
How do myelinated axons signal to the nuclei of cells that enwrap them? The cell bodies of oligodendrocytes and Schwann cells are segregated from axons by multiple layers of bimolecular lipid leaflet… Expand
Schwann cell proliferation during Wallerian degeneration is not necessary for regeneration and remyelination of the peripheral nerves: Axon-dependent removal of newly generated Schwann cells by…
- D. P. Yang, D. Zhang, K. Mak, Daniel E. Bonder, H. Kim
- Medicine, Biology
- Molecular and Cellular Neuroscience
- 1 May 2008
Peripheral nerve injury is followed by a wave of Schwann cell proliferation in the distal nerve stumps. To resolve the role of Schwann cell proliferation during functional recovery of the injured… Expand
FOXF1 promotes angiogenesis and accelerates bevacizumab resistance in colorectal cancer by transcriptionally activating VEGFA.
Forkhead box F1 (FOXF1) has been recently implicated in the progression and metastasis of lung cancer and breast cancer. However, the biological functions and underlying mechanisms by which FOXF1… Expand
Propofol inhibits the adhesion of hepatocellular carcinoma cells by upregulating microRNA-199a and downregulating MMP-9 expression.
- J. Zhang, D. Zhang, Guo-Qing Wu, Z. Feng, S. Zhu
- Biology, Medicine
- Hepatobiliary & pancreatic diseases international…
- 15 June 2013
BACKGROUND Propofol is one of the extensively and commonly used intravenous anesthetics and has the ability to influence the proliferation, motility, and invasiveness of many cancer cells. In this… Expand
The improving effect of spray-drying encapsulation process on the bitter taste and stability of whey protein hydrolysate
Although whey protein hydrolysate (WPH) possesses good physiological functionality, its bitter taste and hygroscopic property limit its direct utilization as food ingredient. The aim of this work was… Expand
SPOP regulates the DNA damage response and lung adenocarcinoma cell response to radiation.
Speckle-type POZ protein (SPOP) plays an important role in maintaining genome stability. Disability or mutation of the SPOP gene has been reported to contribute to prostate cancer incidence and… Expand
Endothelial mechanisms of endothelial dysfunction in patients with obstructive sleep apnea
BackgroundObstructive sleep apnea (OSA) occurs in 2% of middle-aged women and 4% of middle-aged men in the general population and the prevalence is much higher in specific patient groups.… Expand
The anti-ovarian cancer activity by WYE-132, a mTORC1/2 dual inhibitor
Epithelial ovarian cancer is the most common and lethal gynecological cancer in USA and around the world, causing major mortality annually. In the current study, we investigated the potential… Expand
miR-1182 attenuates gastric cancer proliferation and metastasis by targeting the open reading frame of hTERT.
In humans, telomerase reverse transcriptase (hTERT) determines the activity of telomerase. hTERT is an ideal anticancer target because it is universally expressed in cancer cells and plays a crucial… Expand