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Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers.
Although genomic alterations are dominated by loss of tumor suppressor genes, 80% of patients harbored at least one genomic alteration in a targetable gene, suggesting that novel approaches to treatment may be possible for this debilitating subset of head and neck cancers. Expand
Whole-exome and targeted gene sequencing of gallbladder carcinoma identifies recurrent mutations in the ErbB pathway
The identification of somatic mutations for GBC in 57 tumor-normal pairs through a combination of exome sequencing and ultra-deep sequencing of cancer-related genes provides insight into the somatic mutational landscape and highlights the key role of the ErbB signaling pathway in GBC pathogenesis. Expand
Physical and Functional Interaction between Myeloid Cell Leukemia 1 Protein (MCL1) and Fortilin
Data suggest that MCL1, in addition to being an anti-apoptotic molecule, serves as a chaperone of fortilin, binding and stabilizing Fortilin in vivo, maximizing the prosurvival environment in cells. Expand
Metabolic regulation of gene expression through histone acylations
A model is proposed to explain the present understanding of how differential histone acylation is regulated by the metabolism of the different acyl-CoA forms, which in turn modulates the regulation of gene expression. Expand
New insights into the antifibrotic effects of sorafenib on hepatic stellate cells and liver fibrosis.
Sorbenib induces the suppression of collagen accumulation and HSC growth warranting the use of sorafenib as a potential therapeutic agent in the treatment of liver fibrosis. Expand
Development and validation of a deep-learning algorithm for the detection of polyps during colonoscopy
A deep-learning algorithm can detect polyps in the colon in real time and with high sensitivity and specificity, according to validation studies with prospectively collected images and videos from colonoscopies performed in 1,138 patients. Expand
CCR5 Gene Disruption via Lentiviral Vectors Expressing Cas9 and Single Guided RNA Renders Cells Resistant to HIV-1 Infection
Silencing CCR5 via CRISPR associated protein 9 (Cas9) and single guided RNAs (sgRNAs) could be a viable alternative strategy for engineering resistance against HIV-1. Expand
Metformin Improves Functional Recovery After Spinal Cord Injury via Autophagy Flux Stimulation
Improved function recovery was found which was paralleled by a reduction of apoptosis after metformin treatment, which implied met formin to be a potential drug for SCI therapy. Expand
Analysis of the antioxidant capacities of flavonoids under different spectrophotometric assays using cyclic voltammetry and density functional theory.
  • D. Zhang, Le Chu, +9 authors Gang Jia
  • Chemistry, Medicine
  • Journal of agricultural and food chemistry
  • 24 August 2011
Complex reaction mechanisms underlie this method and appropriate structural descriptors for reflecting the AAs of flavonoids based on MOS (e.g., TEAC values) need further investigation. Expand
Binding of the JmjC demethylase JARID1B to LSD1/NuRD suppresses angiogenesis and metastasis in breast cancer cells by repressing chemokine CCL14.
The findings indicate that CCL14 is a critical mediator of the JARID1B/LSD1/NuRD complex in regulation of angiogenesis and metastasis in breast cancer, identifying a novel potential therapeutic target for breast cancer intervention. Expand