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Highly water-soluble platinum(II) complexes as GLUT substrates for targeted therapy: improved anticancer efficacy and transporter-mediated cytotoxic properties.
TLDR
Glucose-conjugated malonato-platinum(II) complexes are designed and synthesized to target tumor-specific active transporters, namely, glucose transporators (GLUTs); the complexes exhibit much higher aqueous solubility and therapeutic index compared to the newest generation of clinical drugs oxaliplatin. Expand
Intramolecular metal-free oxidative aryl-aryl coupling: an unusual hypervalent-iodine-mediated rearrangement of 2-substituted N-phenylbenzamides.
Hypervalent-iodine-mediated oxidative coupling of the two aryl groups in either 2-acylamino-N-phenyl-benzamides or 2-hydroxy-N-phenylbenzamides, with concomitant insertion of the ortho-substituted NExpand
Metal‐Free Synthesis of 3‐Arylquinolin‐2‐ones from N,2‐Diaryl‐ acrylamides via Phenyliodine(III) Bis(2,2‐dimethylpropanoate)‐ Mediated Direct Oxidative C−C Bond Formation
Treatment of N,2-diarylacrylamides with the organoiodine(III) compound phenyliodine(III) bis(2,2-dimethylpropanoate) [PhI(O2C-t-Bu)2] and boron trifluoride etherate (BF3⋅Et2O) resulted in a directExpand
PhI(OAc)2-Mediated Intramolecular Oxidative Aryl-Aldehyde Csp2—Csp2 Bond Formation: Metal-Free Synthesis of Acridone Derivatives.
The newly developed cross-dehydrogenative coupling of various 2-(N-alkyl-N-arylamino)benzaldehydes leads to acridone derivatives, whereas the secondary amine substituted benzaldehyde (III) yieldsExpand
NIS-Mediated Intramolecular Oxidative α-Functionalization of Tertiary Amines: Transition Metal-Free Synthesis of 1,2-Dihydro-(4H)-3,1-benzoxazin-4-one Derivatives.
A novel method for direct α-functionalization of tertiary amines via NIS-mediated oxidative C–O bond formation, where NIS serves both as an oxidant and an iodination reagent, has been developed. TheExpand
Synthesis of oxazoles from enamides via phenyliodine diacetate-mediated intramolecular oxidative cyclization.
TLDR
A group of functionalized oxazoles were synthesized in moderate to good yields from enamides via phenyliodine diacetate (PIDA)-mediated intramolecular cyclization due to its broad substrate scope and the heavy-metal-free characteristic of the oxidative carbon-oxygen bond formation process. Expand
Phenyliodine bis(trifluoroacetate)-mediated oxidative C-C bond formation: synthesis of 3-hydroxy-2-oxindoles and spirooxindoles from anilides.
The reaction of phenyliodine bis(trifluoroacetate) (PIFA) with a series of anilides 1 (E = CO(2)Et) in CF(3)CH(2)OH was found to give 3-hydroxy-2-oxindole derivatives 2, while that with variousExpand
Direct β-acyloxylation of enamines via PhIO-mediated intermolecular oxidative C-O bond formation and its application to the synthesis of oxazoles.
A direct β-acyloxylation of enamine compounds has been achieved by using iodosobenzene (PhIO) as an oxidant to realize the intermolecular oxidative C(sp(2))-O bond formation between enamines andExpand
PhI(OCOCF3)2-mediated C-C bond formation concomitant with a 1,2-aryl shift in a metal-free synthesis of 3-arylquinolin-2-ones.
TLDR
This novel approach features not only metal-free oxidative C(sp(2))-C( sp(2)C(sp-2) bond formation but also an exclusive 1,2-aryl migration. Expand
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