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Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil
TLDR
Molecular clock analysis shows that P.1 emergence occurred around mid-November 2020 and was preceded by a period of faster molecular evolution, which may exhibit increased transmissibility and/or immune evasion, which is critical to accelerate pandemic responsiveness. Expand
Genomics and epidemiology of a novel SARS-CoV-2 lineage in Manaus, Brazil
TLDR
A novel SARS-CoV-2 variant of concern, lineage P.1, that acquired 17 mutations, including a trio in the spike protein associated with increased binding to the human ACE2 receptor, is identified in Manaus, Brazil. Expand
Gram-negative intestinal indigenous microbiota from two Siluriform fishes in a tropical reservoir
TLDR
Environmental factors influenced the Gram-negative intestinal microbiota of both species with possible impact on the interrelationship between the fishes and their digestive ecosystem, although the gut microbiota composition of fishes may result from host-specific selective pressures within the gut. Expand
CD11c+CD123Low Dendritic Cell Subset and the Triad TNF-&agr;/IL-17A/IFN-&ggr; Integrate Mucosal and Peripheral Cellular Responses in HIV Patients With High-Grade Anal Intraepithelial Neoplasia: A
TLDR
The significant association between HSIL and the levels of TNF-&agr;/IL-17A/IFN-&ggr; along with the different subsets of DCs present in the anal mucosa milieu should be studied in more detail as a way to identify and categorize HIV(+) patients vis à vis the high risk of anal cancer outcome. Expand
Distribution, Detection of Enterotoxigenic Strains and Antimicrobial Drug Susceptibility Patterns of Bacteroides Fragilis Group in Diarrheic and Non-Diarrheic Feces from Brazilian Infants
TLDR
The data show that these bacteria are prevalent in fecal microbiota at higher levels in healthy children and the observation of high resistance levels stimulates thoughts about the indiscriminate use of antimicrobial drugs in early infancy. Expand
Inflammatory and Pro-resolving Mediators in Frontotemporal Dementia and Alzheimer’s Disease
TLDR
Differential regulation of inflammatory and pro-resolving mediators in bvFTD and AD is suggested, while AnxA1 cleavage may impair pro-Resolving mechanisms in both groups. Expand
Gene expression profile of cytokines and chemokines in skin lesions from Brazilian Indians with localized cutaneous leishmaniasis.
TLDR
It is suggested that differential gene expression of cytokines and chemokines found in skin lesions from CL patients is associated with time evolution of lesions, as well as the profile of the inflammatory infiltrate by histopathological analysis. Expand
Leptin, hsCRP, TNF-α and IL-6 levels from normal aging to dementia: Relationship with cognitive and functional status
TLDR
The results suggest that TNF-α is associated with cognitive and functional decline and that inflammation could be a substrate of cognitive impairment at early clinical stages of dementia. Expand
Divergent cerebrospinal fluid cytokine network induced by non-viral and different viral infections on the central nervous system
TLDR
Differences in the cytokine profile of the CSF may be unique if distinct, viral or presumably non-viral pathways initially trigger the inflammatory response in the CNS, and may contribute for the design of affordable therapeutic strategies. Expand
Impact of Mitomycin C on the mRNA Expression Signatures of Immunological Biomarkers in Eosinophilic Nasal Polyposis
TLDR
It is observed that the topical use of mitomycin C is important for the reestablishment of the immunologic microenvironment of a normal expression profile of biomarkers involved in ENP mucosal tissue. Expand
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