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The ClinicalTrials.gov results database--update and key issues.
BACKGROUND The ClinicalTrials.gov trial registry was expanded in 2008 to include a database for reporting summary results. We summarize the structure and contents of the results database, provide anExpand
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Prescribing trends in psychotropic medications: primary care, psychiatry, and other medical specialties.
CONTEXT Psychotropic medications are widely prescribed, but how new classes of psychotropic medications have affected prescribing patterns has not been well documented. OBJECTIVE To examine changesExpand
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Publication of NIH funded trials registered in ClinicalTrials.gov: cross sectional analysis
Objective To review patterns of publication of clinical trials funded by US National Institutes of Health (NIH) in peer reviewed biomedical journals indexed by Medline. Design Cross sectionalExpand
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Trial Reporting in ClinicalTrials.gov - The Final Rule.
The final rule for reporting clinical trial results has now been issued by the Department of Health and Human Services. It aims to increase accountability in the clinical research enterprise, makingExpand
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Characteristics of clinical trials registered in ClinicalTrials.gov, 2007-2010.
CONTEXT Recent reports highlight gaps between guidelines-based treatment recommendations and evidence from clinical trials that supports those recommendations. Strengthened reporting requirements forExpand
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A systematic review of pneumatic compression for treatment of chronic venous insufficiency and venous ulcers.
INTRODUCTION As part of a reconsideration of coverage policy, the Centers for Medicare and Medicaid Services requested a systematic review of the evidence on the use of pneumatic compression devicesExpand
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Antidepressant prescribing practices of outpatient psychiatrists.
BACKGROUND The authors examined recent changes in the number and proportion of patients prescribed antidepressants by psychiatrists in outpatient private practice and characterized antidepressantExpand
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Issues in the registration of clinical trials.
Public concerns about the perils associated with incomplete or delayed reporting of results from clinical trials has heightened interest in trial registries and results databases. Here we review theExpand
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Trial Registration at ClinicalTrials.gov between May and October 2005.
BACKGROUND Clinical trial registration allows interested parties to obtain information about ongoing and completed trials, but there are few data indicating the quality of the information providedExpand
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Challenges in Systematic Reviews of Diagnostic Technologies
Diagnostic tests, broadly construed, consist of any method of gathering information that may change a clinician's belief about the probability that a patient has a particular condition. Diagnosis isExpand
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