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Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis.
BACKGROUND Recurrent medulloblastoma is a therapeutic challenge because it is almost always fatal. Studies have confirmed that medulloblastoma consists of at least four distinct subgroups. We soughtExpand
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IFN-γ Determines Distinct Clinical Outcomes in Autoimmune Encephalomyelitis1
Experimental autoimmune encephalomyelitis (EAE) is an inflammatory disease of the CNS initiated by autoreactive CD4+ T cells. EAE classically presents with a progressive ascending paralysis and is aExpand
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IFN-gamma determines distinct clinical outcomes in autoimmune encephalomyelitis.
Experimental autoimmune encephalomyelitis (EAE) is an inflammatory disease of the CNS initiated by autoreactive CD4(+) T cells. EAE classically presents with a progressive ascending paralysis and isExpand
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Horizontal transmission and retention of malignancy, as well as functional human genes, after spontaneous fusion of human glioblastoma and hamster host cells in vivo
Cell fusion in vitro has been used to study cancer, gene mapping and regulation, and the production of antibodies via hybridomas. However, in‐vivo heterosynkaryon formation by cell–cell fusion hasExpand
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Glutamic Acid Decarboxylase Autoantibody Syndrome Presenting as Schizophrenia
Introduction:Glutamic acid decarboxylase (GAD) is the rate-limiting enzyme converting glutamate into &ggr;-aminobutyric acid. Impaired GAD function can alter motor, cognitive, and behavioralExpand
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Primary central nervous system histiocytic sarcoma
Histiocytic sarcoma is a rare, lymphohematopoietic malignant neoplasm composed of tumor cells showing morphologic and immunophenotypic features of mature tissue histiocytes. Involvement of theExpand
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Tissue-specific reduction in splicing efficiency of IKBKAP due to the major mutation associated with familial dysautonomia.
We recently identified a mutation in the I-kappa B kinase associated protein (IKBKAP) gene as the major cause of familial dysautonomia (FD), a recessive sensory and autonomic neuropathy. ThisExpand
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Spontaneously Resolving Seronegative Autoimmune Limbic Encephalitis
ObjectiveWe describe a patient with seronegative autoimmune limbic encephalitis (SNALE) masquerading as glioma. Brain magnetic resonance imaging (MRI) abnormalities, distinctive pathologicalExpand
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Progressive catatonia.
We present the case of a young man with a diagnosis of a childhood-onset pervasive developmental disorder who developed a progressive neurologic deterioration with persistent catatonia and rightExpand
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Unique findings of subependymal giant cell astrocytoma within cortical tubers in patients with tuberous sclerosis complex: a histopathological evaluation
IntroductionTuberous sclerosis is associated with three central nervous system pathologies: cortical/subcortical tubers, subependymal nodules (SENs), and subependymal giant cell astrocytomas (SEGAs).Expand
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