• Publications
  • Influence
Optimal sampling times for pharmacokinetic experiments
  • D. Z. D'Argenio
  • Computer Science, Medicine
  • Journal of Pharmacokinetics and Biopharmaceutics
  • 1 December 1981
A sequential estimation procedure is presented which uses optimal sampling times to estimate the parameters of a model from data obtained from a group of subjects. Expand
  • 188
  • 12
A program package for simulation and parameter estimation in pharmacokinetic systems.
A set of programs is presented which has been developed for parameter estimation and simulation of models arising from pharmacokinetic applications. Expand
  • 522
  • 11
Experimental design for estimating integrals by numerical quadrature, with applications to pharmacokinetic studies.
Many experimental situations, including bioavailability studies, require the estimation of integrals by numerical quadrature applied to dependent variable observations with measurement error. AExpand
  • 25
  • 4
Targeting the systemic exposure of teniposide in the population and the individual using a stochastic therapeutic objective
A stochastic control approach for dose regimen design is developed and applied to the problem of targeting the systemic exposure, defined as the area under the blood concentrationtime curve (AUC),ofExpand
  • 17
  • 2
Computer assessment of hemodynamic severity of coronary artery stenosis from angiograms.
A computer-assisted analysis of coronary obstructions from cineangiograms, which includes both the geometric and hemodynamic evaluation of coronary stenosis severity. Expand
  • 21
  • 1
Stochastic control of pharmacokinetic systems
An alternative approach utilizing stochastic control theory to the clinical problem of designing a dosage regimen for a pharmacokinetic system in which the estimation and control phases of the problem are not separated. Expand
  • 15
  • 1
Adaptive control of theophylline therapy: Importance of blood sampling times
A two-observation protocol for estimating theophylline clearance during a constant-rate intravenous infusion is used to examine the importance of blood sampling schedules with regard to theExpand
  • 11
  • 1
Nonlinear random effects mixture models: Maximum likelihood estimation via the EM algorithm
We propose a parametric approach using finite mixture models to identify polymorphism in pharmacokinetic/pharmacodynamic phenotypes with distinct PK/PD properties. Expand
  • 22
  • 1
  • PDF
Sampling strategies for noncompartmental estimation of mean residence time
An optimization procedure is presented for selecting sample times for estimating mean residence time using noncompartmental data analysis. Performance of this experimental design strategy isExpand
  • 9
  • 1