Dichloroacetate shifts the metabolism from glycolysis to glucose oxidation and exhibits synergistic growth inhibition with cisplatin in HeLa cells.
- J. Xie, Bing-Shun Wang, Hongzhuan Chen
- BiologyInternational Journal of Oncology
- 1 February 2011
The specific apoptotic mechanism of DCA as distinguished from the cisplatin may be partly responsible for the synergy and further in vivo study on combination chemotherapy of the two agents in cervical cancer xenografts in mice is warranted.
Antiangiogenic triterpenes isolated from Chinese herbal medicine Actinidia chinensis Planch.
- Wen-jun Zhu, D. Yu, Hong-Zhuan Chen
- ChemistryAnti-Cancer Agents in Medicinal Chemistry
- 31 January 2013
The findings suggest that antitumor action of Actinidia chinensis Planch is partly via inhibiting tumor angiogenesis by triterpenes, and compounds 2, 3, 4, and 8 as the novel potential antiangiogenic agents are worthy of further translational research.
Peptide-conjugated biodegradable nanoparticles as a carrier to target paclitaxel to tumor neovasculature.
- D. Yu, Q. Lu, J. Xie, Chao Fang, Hong-Zhuan Chen
- Biology, ChemistryBiomaterials
- 1 March 2010
Determination of Raddeanin A in rat plasma by liquid chromatography-tandem mass spectrometry: application to a pharmacokinetic study.
- Xin Luan, Ying‐Yun Guan, Hong-Zhuan Chen
- ChemistryJournal of chromatography. B, Analytical…
- 1 April 2013
Secolignans with Antiangiogenic Activities from Peperomia dindygulensis
- Meng-Gan Lin, D. Yu, Guo-Hong Yang
- ChemistryChemistry and Biodiversity
- 1 May 2011
Two new secolignans, peperomins G and H (1 and 2, resp.), were isolated from the whole plant of Peperomia dindygulensis and their structures and configurations were elucidated by spectroscopic methods including 2D‐NMR techniques.
IF7-Conjugated Nanoparticles Target Annexin 1 of Tumor Vasculature against P-gp Mediated Multidrug Resistance.
- D. Yu, Yarong Liu, Hong-Zhuan Chen
- Biology, ChemistryBioconjugate chemistry
- 26 June 2015
The anticancer efficacy of IF7-PTX-NP was strongly associated with the improved antiangiogenic effect, evident as a dramatic reduction in the tumor microvessel density and pronounced increase in apoptotic tumor cells, with no obvious toxicity to the mice.
Antiangiogenic Polyketides from Peperomia dindygulensis Miq
- Qi-Wei Wang, D. Yu, Guo-Hong Yang
- ChemistryMolecules
- 1 April 2012
Two new polyketides are isolated from the whole plant of Peperomia dindygulensis Miq and their structures were elucidated by spectroscopic methods, including 2D-NMR techniques.
The use of nanoparticulate delivery systems in metronomic chemotherapy.
- D. Yu, F. Ban, Hong-Zhuan Chen
- BiologyBiomaterials
- 1 May 2013
Influence of E3 region on conditionally replicative adenovirus mediated cytotoxicity in hepatocellular carcinoma cells
- Q. Lu, D. Yu, Hong-Zhuan Chen
- BiologyCancer Biology & Therapy
- 15 June 2009
The findings provided the first evidence that CRAd without E3 region might be a smart choice for the virotherapy of HCC, and suggested that the endogenous TRAIL-mediated apoptotic pathway may be implicated in the cytocidal potency of Ad.ΔE1B.