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Salmahyrtisol A, a novel cytotoxic sesterterpene from the Red Sea sponge Hyrtios erecta.
The lipophilic partition of a methanol extract of the Red Sea sponge Hyrtios erecta yielded a novel pentacyclic sesterterpene ester salmahyrtisol A, which shows significant cytotoxicity to murine leukemia, human lung carcinoma, and human colon carcinoma. Expand
Latrunculin A and its C-17-O-carbamates inhibit prostate tumor cell invasion and HIF-1 activation in breast tumor cells.
The marine-derived macrolides latrunculins A ( 1) and B, from the Red Sea sponge Negombata magnifica, have been found to reversibly bind actin monomers, forming a 1:1 complex with G-actin andExpand
Theonellamide G, a Potent Antifungal and Cytotoxic Bicyclic Glycopeptide from the Red Sea Marine Sponge Theonella swinhoei
The polar fraction of the organic extract of the Red Sea sponge Theonella swinhoei yielded a new bicyclic glycopeptide, theonellamide G, which showed potent antifungal activity towards wild and amphotericin B-resistant strains of Candida albicans and cytotoxic activity against the human colon adenocarcinoma cell line. Expand
Hyrtiazepine, an azepino-indole-type alkaloid from the Red Sea marine sponge Hyrtios erectus.
The structures of a novel azepino-indole-type alkaloid named hyrtiazepine and 5-hydroxy-1H-indoles-3-carboxylic acid methyl ester were elucidated on the basis of mass spectrometry and detailed 2D NMR spectroscopic data. Expand
Penicillivinacine, antimigratory diketopiperazine alkaloid from the marine-derived fungus Penicillium vinaceum
A new alkaloid with an unprecedented carbon skeleton, penicillivinacine together with six previously reported ones were isolated and displayed potent antimigratory activities against the highly metastatic triple negative human breast cancer cells MDA-MB-231. Expand
Constituents of the Egyptian Centaurea scoparia. III. Phenolic constituents of the aerial parts.
The ethanolic extract of the aerial parts of Centaurea scoparia Sieb. (Asteraceae) afforded five polyoxygenated flavones apigenin, luteolin, salvigenin, cirsimaritin, and hispidulin, the two lignansExpand
New ursane-type triterpenes from the root bark of Calotropis procera
Abstract As a part of our continuing interest in identifying anticancer drug leads from natural sources, we have investigated the in vitro growth inhibitory effects of the hexane fraction of the rootExpand
Acetophenones, a chalcone, a chromone and flavonoids from Pancratium maritimum
Abstract The ethanolic extract of fresh flowering bulbs of Pancratium maritimum L. yielded a new chromone, maritimin, two new polyoxygenated acetophenones, together with the flavonoids syzalterin,Expand
Hyrtioerectines A-C, cytotoxic alkaloids from the red sea sponge hyrtioserectus.
  • D. Youssef
  • Chemistry, Medicine
  • Journal of natural products
  • 16 August 2005
A Red Sea specimen of the marine sponge Hyrtios erectus was found to contain three new alkaloids, hyrtioerectines A-C (1-3). Hyrtioerectine A (1) possesses the carbon bond-linked moieties 6-hydroxyExpand
Hurghadolide A and swinholide I, potent actin-microfilament disrupters from the Red Sea sponge Theonella swinhoei.
The isolation and structure elucidation of swin holide A and two new macrolides, swinholide I and hurghadolide A, which showed in vitro cytotoxicity against human colon adenocarcinoma and Candida albicans are reported. Expand