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Small-molecule inhibitors of microrna miR-21 function.
TLDR
A cellular screen is reported for miRNA pathway inhibitors and the first small molecule modifiers of miRNA function, which are likely to be important tools to elucidate the detailed mechanisms of mi RNA function and provide lead structures for the development of new therapeutics.
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Small molecule modifiers of microRNA miR-122 function for the treatment of hepatitis C virus infection and hepatocellular carcinoma.
TLDR
The authors' small molecule inhibitors reduce viral replication in liver cells and represent a new approach to the treatment of HCV infections and small molecule activation of miR-122 in liver cancer cells selectively induced apoptosis through caspase activation, thus having implications in cancer chemotherapy.
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Photochemical activation of protein expression in bacterial cells.
TLDR
A light-inducible gene-expression system which can be used in bacterial cells, plants, and mammalian organisms is reported, based on the lactose (lac) repressor which binds to the lac operator ( lacO), thereby inhibiting RNA polymerase from performing gene transcription.
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Photochemical control of biological processes.
TLDR
This report summarizes the advances made in recent years, focusing predominantly on the in vivo regulation of gene function using irradiation with UV light, using photocaging groups installed either on a small molecule modulator of biomolecular function or directly on a biological macromolecule itself.
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An evolved aminoacyl-tRNA synthetase with atypical polysubstrate specificity.
TLDR
It is discovered that a p-cyanophenylalanine specific aminoacyl-tRNA synthetase (pCNF-RS) has high substrate permissivity for unnatural amino acids, while maintaining its ability to discriminate against the 20 canonical amino acids.
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Microwave activation of enzymatic catalysis.
TLDR
This is the first illustration of a specific microwave effect in enzymatic catalysis, used to regulate biocatalysis, in a microwave reactor.
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Incorporation of fluorotyrosines into ribonucleotide reductase using an evolved, polyspecific aminoacyl-tRNA synthetase.
TLDR
The directed evolution of aminoacyl-tRNA synthetases (aaRSs) for 2,3,5-trifluorotyrosine (2,1,4-F(3)Y) and their ability to charge an orthogonal tRNA with a series of F(n)Ys while maintaining high specificity over Y is presented.
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Playing with the Molecules of Life.
TLDR
One example in which the genetic code itself has been expanded with new building blocks that allow chemists to probe and manipulate the structures and functions of proteins with unprecedented precision is reviewed.
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Light regulation of protein dimerization and kinase activity in living cells using photocaged rapamycin and engineered FKBP.
We developed a new system for light-induced protein dimerization in living cells using a photocaged analogue of rapamycin together with an engineered rapamycin binding domain. Using focal adhesion…
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Photocaged T7 RNA Polymerase for the Light Activation of Transcription and Gene Function in Pro‐ and Eukaryotic Cells
TLDR
The ability to achieve spatiotemporal regulation of orthogonal RNA synthesis enables the precise dissection and manipulation of a wide range of cellular events, including gene function.
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