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Two endothelin 1 effectors, hand2 and bapx1, pattern ventral pharyngeal cartilage and the jaw joint
TLDR
Together the results reveal two critical edn1 effectors that pattern the vertebrate jaw: hand2 specifies ventral pharyngeal cartilage of the lower jaw and bapx1 specifies the jaw joint. Expand
Restricted expression of cardiac myosin genes reveals regulated aspects of heart tube assembly in zebrafish.
TLDR
Examination of expression patterns of two zebrafish cardiac myosin genes allow us to distinguish two populations of myocardial precursors at an early stage, well before the heart tube forms and suggest new models for the mechanisms that regulate the formation of a patterned heart tube. Expand
Vessel and blood specification override cardiac potential in anterior mesoderm.
TLDR
A mechanism for restricting heart size through confinement of the developmental potential of the heart field is identified and this regulatory relationship between cardiovascular pathways suggests strategies for directing progenitor cell differentiation to facilitate cardiac regeneration. Expand
Gata5 is required for the development of the heart and endoderm in zebrafish.
TLDR
Together, these results implicate zebrafish Gata5 in controlling the growth, morphogenesis, and differentiation of the heart and endoderm and indicate that gata5 regulates the expression of the early myocardial gene nkx2.5. Expand
The bHLH transcription factor hand2 plays parallel roles in zebrafish heart and pectoral fin development.
TLDR
These studies reveal early functions for Hand2 in several cellular processes and highlight a genetic parallel between heart and forelimb development. Expand
Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42.
TLDR
It is shown that, in T cells, the mammalian Ras-related GTPase CDC42 can regulate the polarization of both actin and microtubules toward antigen-presenting cells but is not involved in other T-cell signaling processes such as those which culminate in interleukin 2 production. Expand
Distinct phases of cardiomyocyte differentiation regulate growth of the zebrafish heart
TLDR
The data support a model in which modified regulation of these distinct phases of cardiomyocyte differentiation has been responsible for the changes in heart size and morphology among vertebrate species. Expand
Functional Modulation of Cardiac Form through Regionally Confined Cell Shape Changes
TLDR
It is demonstrated that chamber morphology develops via changes in cell morphology, and key regulatory influences on this process are determined, and regionally confined cell shape change is established as a cellular mechanism for chamber emergence and as a link in the relationship between form and function during organ morphogenesis. Expand
casanova encodes a novel Sox-related protein necessary and sufficient for early endoderm formation in zebrafish.
TLDR
It is shown that cas encodes a novel member of the Sox family of transcription factors, which is the principal transcriptional effector of Nodal signaling during zebrafish endoderm formation. Expand
The zebrafish bonnie and clyde gene encodes a Mix family homeodomain protein that regulates the generation of endodermal precursors.
TLDR
It is shown that the zebrafish bonnie and clyde (bon) gene plays a critical early role in endoderm formation and that Bon functions exclusively downstream of cyclops and squint signaling, and is a critical transcriptional regulator of early endodermal formation. Expand
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