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- Publications
- Influence
Melanocortin receptor signaling through mitogen-activated protein kinase in vitro and in rat hypothalamus
- D. Daniels, C. Patten, J. Roth, D. Yee, S. Fluharty
- Biology, Medicine
- Brain Research
- 3 October 2003
The central melanocortin system has emerged as a potential regulator of food intake. This action of melanocortins appears to occur through intrahypothalamic, melanocortin-containing projections,… Expand
Divergent behavioral roles of angiotensin receptor intracellular signaling cascades.
- D. Daniels, D. Yee, L. Faulconbridge, S. Fluharty
- Biology, Medicine
- Endocrinology
- 1 December 2005
Central injections of angiotensin II (AngII) increase both water and NaCl intake. These effects of AngII occur largely through stimulation of the AngII type 1 (AT(1)) receptor. Stimulation of the… Expand
Mutational analysis of the angiotensin II type 2 receptor: contribution of conserved extracellular amino acids
- J. Heerding, D. Yee, S. Jacobs, S. Fluharty
- Biology, Medicine
- Regulatory Peptides
- 31 October 1997
While much work has been done examining the ligand-binding characteristics of the AT1 receptor, very little attention has been focused on the AT2 receptor. Both receptors bind angiotensin II (AngII)… Expand
Structural determinants for the activation mechanism of the angiotensin II type 1 receptor differ for phosphoinositide hydrolysis and mitogen-activated protein kinase pathways.
- J. Hines, S. Fluharty, D. Yee
- Biology, Medicine
- Biochemical pharmacology
- 15 July 2003
While the mechanism whereby the angiotensin II type 1 receptor (AT(1) receptor) activates its classical effector phospholipase C-beta (PLC-beta) has largely been elucidated, there is little consensus… Expand
Identification of structural determinants for G protein-independent activation of mitogen-activated protein kinases in the seventh transmembrane domain of the angiotensin II type 1 receptor.
- D. Yee, A. Suzuki, Laiyi Luo, S. Fluharty
- Medicine, Biology
- Molecular endocrinology
- 1 August 2006
Although the intrareceptor mechanisms whereby the angiotensin II (AngII) type 1 receptor activates phospholipase C (PLC) have been extensively investigated, analogous studies of signaling through… Expand
Identification of angiotensin II type 2 (AT2) receptor domains mediating high-affinity CGP 42112A binding and receptor activation.
- J. Hines, J. Heerding, S. Fluharty, D. Yee
- Chemistry, Medicine
- The Journal of pharmacology and experimental…
- 1 August 2001
Chimeric angiotensin II (AngII) receptors constructed of portions of the AT2 receptor substituted into the AT1 receptor revealed the AT2 third extracellular loop and seventh transmembrane-spanning… Expand
Modeling the pathways of energy balance using the N1E-115 murine neuroblastoma cell line.
- J. Roth, D. Yee, L. R. Kisley, S. Fluharty
- Biology, Medicine
- Brain research. Molecular brain research
- 30 June 2002
A good in vitro model within which to investigate molecular interactions between feeding relevant neuropeptide systems has been lacking. Consequently, we began using reverse transcriptase-polymerase… Expand
Immunohistochemical mapping of angiotensin type 2 (AT2) receptors in rat brain
- L. Reagan, L. M. Flanagan-Cato, D. Yee, Li-yun Ma, S. Fluharty
- Biology, Medicine
- Brain Research
- 31 October 1994
Recently developed antisera selective for angiotensin Type 2 (AT2) receptors were used to localize AT2 receptors in rat brain by immunohistochemistry. While the results from these experiments were… Expand
Oxidative stress and HNE conjugation of GLUT3 are increased in the hippocampus of diabetic rats subjected to stress
- L. Reagan, A. M. Magariños, D. Yee, Luke I Swzeda, B. McEwen
- Biology, Medicine
- Brain Research
- 17 April 2000
Recent studies demonstrate that cellular, molecular and morphological changes induced by stress in rats are accelerated when there is a pre-existing strain upon their already compromised adaptive… Expand
Biochemical Characterization of Two Distinct Angiotensin AT2 Receptor Populations in Murine Neuroblastoma N1E‐115 Cells
- I. Siemens, L. Reagan, D. Yee, S. Fluharty
- Chemistry, Medicine
- Journal of neurochemistry
- 1 June 1994
Abstract: The murine neuroblastoma N1E‐115 cell line possesses a high density of angiotensin II (Angll) receptors that can be solubilized with the zwitterionic detergent… Expand
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