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Green fluorescent protein variants as ratiometric dual emission pH sensors. 1. Structural characterization and preliminary application.
Novel dual emission, pH-sensitive variants of the green fluorescent protein (GFP) have been constructed and are suitable for ratiometric emission measurements in vivo. This new class of GFPs, termedExpand
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Targeted Killing of Streptococcus mutans by a Pheromone-Guided “Smart” Antimicrobial Peptide
ABSTRACT Within the repertoire of antibiotics available to a prescribing clinician, the majority affect a broad range of microorganisms, including the normal flora. The ecological disruptionExpand
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zFP538, a yellow-fluorescent protein from Zoanthus, contains a novel three-ring chromophore.
Crystal structures of the tetrameric yellow-fluorescent protein zFP538 from the button polyp Zoanthus sp. and a green-emitting mutant (K66M) are presented. The atomic models have been refined at 2.7Expand
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Novel Synthetic Antimicrobial Peptides against Streptococcus mutans
  • J. He, R. Eckert, +6 authors W. Shi
  • Biology, Medicine
  • Antimicrobial Agents and Chemotherapy
  • 12 February 2007
ABSTRACT Streptococcus mutans, a common oral pathogen and the causative agent of dental caries, has persisted and even thrived on the tooth surface despite constant removal and eradication efforts.Expand
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Adding Selectivity to Antimicrobial Peptides: Rational Design of a Multidomain Peptide against Pseudomonas spp
ABSTRACT Currently available antimicrobials exhibit broad killing with regard to bacterial genera and species. Indiscriminate killing of microbes by these conventional antibiotics can disrupt theExpand
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Systematic Approach to Optimizing Specifically Targeted Antimicrobial Peptides against Streptococcus mutans
ABSTRACT Previously we reported a novel strategy of “targeted killing” through the design of narrow-spectrum molecules known as specifically targeted antimicrobial peptides (STAMPs) (R. Eckert etExpand
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The cia operon of Streptococcus mutans encodes a unique component required for calcium‐mediated autoregulation
Streptococcus mutans is a primary pathogen for dental caries in humans. CiaR and CiaH of S. mutans comprise a two‐component signal transduction system (TCS) involved in regulating various virulentExpand
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Specific Binding and Mineralization of Calcified Surfaces by Small Peptides
Several small (<25aa) peptides have been designed based on the sequence of the dentin phosphoprotein, one of the major noncollagenous proteins thought to be involved in the mineralization of theExpand
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Enhancement of Antimicrobial Activity against Pseudomonas aeruginosa by Coadministration of G10KHc and Tobramycin
ABSTRACT Pseudomonas aeruginosa is a common opportunistic human pathogen that is associated with life-threatening acute infections and chronic airway colonization during cystic fibrosis. Previously,Expand
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Targeted Antimicrobial Therapy Against Streptococcus mutans Establishes Protective Non-cariogenic Oral Biofilms and Reduces Subsequent Infection
  • Li-na Li, L. Guo, +5 authors W. Shi
  • Biology, Medicine
  • International Journal of Oral Science
  • 1 June 2010
AimDental biofilms are complex communities composed largely of harmless bacteria. Certain pathogenic species including Streptococcus mutans (S. mutans) can become predominant when host factors suchExpand
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