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- D. -Y. Sun, Hans Lennernas, +6 authors Gordon L Amidon
- Pharmaceutical Research
- 2002
Purpose. To compare gene expression profiles and drug permeability differences in Caco-2 cell culture and human duodenum. Methods. Gene expression profiles in Caco-2 cells and human duodenum were… (More)
- Qian Cai, Haiying Sun, +15 authors Shaomeng Wang
- Journal of medicinal chemistry
- 2011
We report the discovery and characterization of SM-406 (compound 2), a potent and orally bioavailable Smac mimetic and an antagonist of the inhibitor of apoptosis proteins (IAPs). This compound binds… (More)
- Yanyan Li, Tao Zhang, +8 authors D. -Y. Sun
- Clinical cancer research : an official journal of…
- 2010
PURPOSE
The existence of cancer stem cells (CSCs) in breast cancer has profound implications for cancer prevention. In this study, we evaluated sulforaphane, a natural compound derived from… (More)
- Tao Zhang, Adel Hamza, +4 authors D. -Y. Sun
- Molecular cancer therapeutics
- 2008
Pancreatic cancer is an aggressive disease with multiple biochemical and genetic alterations. Thus, a single agent to hit one molecular target may not be sufficient to treat this disease. The purpose… (More)
- Xiaokai Li, Sharan R. Srinivasan, +6 authors Jason E. Gestwicki
- ACS medicinal chemistry letters
- 2013
The rhodacyanine, MKT-077, has anti-proliferative activity against cancer cell lines through its ability to inhibit members of the heat shock protein 70 (Hsp70) family of molecular chaperones.… (More)
- Dmitry Borkin, Shihan He, +20 authors Jolanta Grembecka
- Cancer cell
- 2015
Chromosomal translocations affecting mixed lineage leukemia gene (MLL) result in acute leukemias resistant to therapy. The leukemogenic activity of MLL fusion proteins is dependent on their… (More)
- Yanke Yu, Adel Hamza, +7 authors D. -Y. Sun
- Biochemical pharmacology
- 2010
The purpose of this study is to investigate the efficacy and the mechanism of Hsp90 inhibition of Withaferin A (WA), a steroidal lactone occurring in Withania somnifera, in pancreatic cancer in vitro… (More)
- Rong Zhou, Paul A Moench, +7 authors D. -Y. Sun
- Pharmaceutical Research
- 2004
The aim of this research was to develop a pH-dependent canine absorption model for studying pH effect on both dissolution in vitro and pharmacokinetics in vivo using the weak bases ketoconazole and… (More)
- Xianhua Cao, Seth T. Gibbs, +8 authors D. -Y. Sun
- Pharmaceutical Research
- 2006
To study the correlation of intestinal absorption for drugs with various absorption routes between human and rat, and to explore the underlying molecular mechanisms for the similarity in drug… (More)
- Lanyan Fang, Nick H G Holford, +10 authors D. -Y. Sun
- Journal of clinical pharmacology
- 2007
To predict the optimal time for surgery after antibody administration, the population pharmacokinetics of (125)I-HuCC49deltaCH2 and (125)I-CC49 were characterized in 55 patients with colorectal… (More)