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Role of inducible bronchus associated lymphoid tissue (iBALT) in respiratory immunity
TLDR
It is shown that mice lacking spleen, lymph nodes and Peyer's patches generate unexpectedly robust primary B- and T-cell responses to influenza, which seem to be initiated at sites of induced BALT (iBALT), which functions as an inducible secondary lymphoid tissue for respiratory immune responses.
Activation phenotype, rather than central– or effector–memory phenotype, predicts the recall efficacy of memory CD8+ T cells
TLDR
It is demonstrated that activation markers, such as CD27 and CD43, define three distinct subpopulations of memory CD8+ T cells that differ in their capacities to mount recall responses, and suggested that activation and migration markers define distinct, and unrelated, characteristics of memory T cells.
Activated Antigen-Specific CD8+ T Cells Persist in the Lungs Following Recovery from Respiratory Virus Infections1
TLDR
A substantial population of Ag-specific CD8+ T cells in the lung that persist for several months after recovery from an influenza or Sendai virus infection is identified.
Differential Antigen Presentation Regulates the Changing Patterns of CD8+ T Cell Immunodominance in Primary and Secondary Influenza Virus Infections
The specificity of CD8+ T cell responses can vary dramatically between primary and secondary infections. For example, NP366–374/Db- and PA224–233/Db-specific CD8+ T cells respond in approximately
Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus
TLDR
It is shown in a mouse infection model that naturally occurring contraction of the naive T cell repertoire can result in impaired CD8 T cell responses to known immunodominant epitopes and decline in heterosubtypic immunity, which has important implications for the design of vaccine strategies for the elderly.
Immunity to respiratory viruses.
TLDR
Recent advances that describe the roles of individual components during primary and secondary responses to respiratory virus infections and how these discoveries have added to the understanding of antiviral immunity in the lung are discussed.
γ-Herpesvirus Latency Is Preferentially Maintained in Splenic Germinal Center and Memory B Cells
TLDR
Analysis of viral gene expression showed that both lytic and latent viral transcripts were differentially expressed in germinal center and memory B cells during long-term latency, which suggested that γ-herpesviruses exploit the B cell life cycle in the spleen.
Distinct functions of antigen-specific CD4 T cells during murine Mycobacterium tuberculosis infection
TLDR
It is suggested that antigen-specific T-cell responses are maintained during chronic mycobacterial infection through the continual production of terminal effector cells from a proliferating precursor population.
Differential contributions of central and effector memory T cells to recall responses
TLDR
A progressive increase in the quality of memory T cell pools in terms of their ability to proliferate and accumulate at effector sites in response to secondary pathogen challenge is demonstrated.
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