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Mephedrone use and associated adverse effects in school and college/university students before the UK legislation change.
TLDR
It is shown in this study that the use of mephedrone among school and college/university students is common and that users found it easy to obtain and that there was a high prevalence of unwanted effects associated with its use.
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2,4-Dinitrophenol (DNP): A Weight Loss Agent with Significant Acute Toxicity and Risk of Death
TLDR
The pattern and pathophysiology of DNP toxicity is described, the previous fatalities associated with exposure to DNP are summarised and the current and previous fatalities related to exposure are summarized.
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Novel psychoactive substances: classification, pharmacology and toxicology.
TLDR
This book covers individual classes of novel psychoactive substances that have recently emerged onto the recreational drug scene and provides an overview of the pharmacology of the substance followed by a discussion of the acute and chronic harm or toxicity associated with the substance.
The epidemiology and patterns of acute and chronic toxicity associated with recreational ketamine use
TLDR
The available information on the epidemiology of recreational use of ketamine is collated and the patterns of acute and chronic toxicity associated with its recreational use and the management of this toxicity are described.
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Acute recreational drug and new psychoactive substance toxicity in Europe: 12 months data collection from the European Drug Emergencies Network (Euro-DEN)
TLDR
The Euro-DEN dataset provides a unique insight into the drugs involved in and clinical pattern of toxicity/outcome of acute recreational drug toxicity presentations to hospitals around Europe, complimentary to other indicators of drug-related harm and helps to build a fuller picture of the public health implications of drug use in Europe.
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Acute toxicity associated with the recreational use of the ketamine derivative methoxetamine
TLDR
These three analytically confirmed cases demonstrate that acute methoxetamine-related toxicity is associated with both “dissociative” and “sympathomimetic” clinical features, and is useful to clinical pharmacologists, not only in managing individuals with acute methxetamine toxicity but also in advising the appropriate legislative authorities on the risk of acute harm related to methoxETamine use.
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Effect of the UK’s revised paracetamol poisoning management guidelines on admissions, adverse reactions and costs of treatment
TLDR
The changes introduced by the CHM in September 2012 have increased the numbers of patients admitted to hospital and treated with acetylcysteine without reducing adverse reactions, and the estimated cost impact is ÂŁ8.3 million annually.
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Misuse of the Îł-aminobutyric acid analogues baclofen, gabapentin and pregabalin in the UK.
TLDR
The aim of this study was to determine the prevalence, frequency and sources of misuse of the GABA analogues (baclofen, gabapentin and pregabalin) in the UK, and to benchmark against existing national data provided by the 2011/2012 Crime Survey for England and Wales.
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Risk stratification after paracetamol overdose using mechanistic biomarkers: results from two prospective cohort studies
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Limited use of novel psychoactive substances in South London nightclubs.
TLDR
It seems that only mephedrone has become an established part of the recreational drug scene, and it is important that there is a considered approach to determining the utilization of drug prevention/education and enforcement budgets to ensure that this is appropriately targeted to drugs that are used recreationally.
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