Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice
- J. Peschon, P. Morrissey, B. Davison
- Biology, MedicineJournal of Experimental Medicine
- 1 November 1994
Significantly, these studies indicate that the phase of thymocyte expansion occurring before the onset of T cell receptor gene rearrangement is critically dependent upon, and mediated by the high affinity receptor for IL-7.
Steel-Dickie mutation encodes a c-kit ligand lacking transmembrane and cytoplasmic domains.
These studies provide a molecular basis for explaining the Sld phenotype, a description of a germ-line mutation in the transmembrane and cytoplasmic domains of a membrane- bound growth factor, and in vivo evidence for the importance of membrane-bound forms of growth factors in mammalian development.
Bioaccumulation and clearance of microcystins from salt water mussels, Mytilus edulis, and in vivo evidence for covalently bound microcystins in mussel tissues.
Evidence for a covalently bound form of microcystin-LR in salmon liver and Dungeness crab larvae.
The Lemieux oxidation-GC/MS method detected 10,000-fold greater microcystin concentrations in Cypress Island Dungeness crab larvae than did the MeOH extraction-PPase method, and is taken as direct evidence for the existence of covalently boundmicrocystins in vivo.
Fish models for environmental carcinogenesis: the rainbow trout.
There are many aspects of the trout model, especially the lack of complete organ homology, that limit its application as a surrogate for human cancer research, but it is apparent that trout and other fish models can serve as highly useful adjuncts to conventional rodent models in the study of environmental carcinogenesis and its modulation.
A cross-sectional study of dietary patterns with glucose intolerance and other features of the metabolic syndrome
- D. Williams, A. Prevost, M. Whichelow, B. Cox, N. Day, N. Wareham
- MedicineBritish Journal of Nutrition
- 1 March 2000
The hypothesis that dietary patterns are associated with other lifestyle factors and with glucose intolerance and other features of the metabolic syndrome are supported, and the recommendation of a healthy balanced diet is provided as one of the main components of chronic disease prevention.
Lung cancer mortality in the Mayo Lung Project: impact of extended follow-up.
Extended follow-up of MLP participants did not reveal a lung cancer mortality reduction for the intervention arm, which indicates that some lesions with limited clinical relevance may have been identified in the Intervention arm.
Chemical and biological evidence links microcystins to salmon 'netpen liver disease'.
Cytokine stimulation of multilineage hematopoiesis from immature human cells engrafted in SCID mice.
- T. Lapidot, F. Pflumio, M. Doedens, B. Murdoch, D. Williams, J. Dick
- Biology, MedicineScience
- 28 February 1992
Severe combined immunodeficient mice transplanted with human bone marrow were treated with human mast cell growth factor, a fusion of interleukin-3 and granulocyte-macrophage colony-stimulating factor (PIXY321), or both, and this system allows the detection of immature human cells, identification of the growth factors that regulate them, and the establishment of animal models of human hematopoietic diseases.
Sphingolipid perturbations as mechanisms for fumonisin carcinogenesis.
The balance between the rates of apoptosis and proliferation is important in tumorigenesis, cells sensitive to the proliferative effect of decreased CER and increased sphingosine 1-phosphate may be selected to survive and proliferate when free sphingoid base concentration is not growth inhibitory.