• Publications
  • Influence
Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice
TLDR
Significantly, these studies indicate that the phase of thymocyte expansion occurring before the onset of T cell receptor gene rearrangement is critically dependent upon, and mediated by the high affinity receptor for IL-7. Expand
A cross-sectional study of dietary patterns with glucose intolerance and other features of the metabolic syndrome
TLDR
The hypothesis that dietary patterns are associated with other lifestyle factors and with glucose intolerance and other features of the metabolic syndrome are supported, and the recommendation of a healthy balanced diet is provided as one of the main components of chronic disease prevention. Expand
Bioaccumulation and clearance of microcystins from salt water mussels, Mytilus edulis, and in vivo evidence for covalently bound microcystins in mussel tissues.
TLDR
Direct evidence was provided for the existence of covalently bound microcystins in mussel tissues in vivo and it is concluded that in any shellfish monitoring program it is the total tissuemicrocystin burden that needs to be considered. Expand
Steel-Dickie mutation encodes a c-kit ligand lacking transmembrane and cytoplasmic domains.
TLDR
These studies provide a molecular basis for explaining the Sld phenotype, a description of a germ-line mutation in the transmembrane and cytoplasmic domains of a membrane- bound growth factor, and in vivo evidence for the importance of membrane-bound forms of growth factors in mammalian development. Expand
Chemical and biological evidence links microcystins to salmon 'netpen liver disease'.
TLDR
Intraperitoneal injection of microcystin-LR into healthy Atlantic salmon re-created the pathologic changes of netpen liver disease, including diffuse necrosis and hepatic megalocytosis. Expand
Lung cancer mortality in the Mayo Lung Project: impact of extended follow-up.
TLDR
Extended follow-up of MLP participants did not reveal a lung cancer mortality reduction for the intervention arm, which indicates that some lesions with limited clinical relevance may have been identified in the Intervention arm. Expand
Sphingolipid perturbations as mechanisms for fumonisin carcinogenesis.
TLDR
The balance between the rates of apoptosis and proliferation is important in tumorigenesis, cells sensitive to the proliferative effect of decreased CER and increased sphingosine 1-phosphate may be selected to survive and proliferate when free sphingoid base concentration is not growth inhibitory. Expand
Evidence for a covalently bound form of microcystin-LR in salmon liver and Dungeness crab larvae.
TLDR
The Lemieux oxidation-GC/MS method detected 10,000-fold greater microcystin concentrations in Cypress Island Dungeness crab larvae than did the MeOH extraction-PPase method, and is taken as direct evidence for the existence of covalently boundmicrocystins in vivo. Expand
Fish models for environmental carcinogenesis: the rainbow trout.
TLDR
There are many aspects of the trout model, especially the lack of complete organ homology, that limit its application as a surrogate for human cancer research, but it is apparent that trout and other fish models can serve as highly useful adjuncts to conventional rodent models in the study of environmental carcinogenesis and its modulation. Expand
Hematologic effects of flt3 ligand in vivo in mice.
TLDR
It is concluded that FL, when administered as a single agent, is a potent mobilizer of hematopoietic progenitors into the PB of FL-treated mice with similar kinetics and magnitude to that ofCFU-GM and CFU-GEMM. Expand
...
1
2
3
4
5
...