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Retinoid Signaling Determines Germ Cell Fate in Mice
TLDR
It is found that retinoic acid, produced by mesonephroi of both sexes, causes germ cells in the ovary to enter meiosis and inititate oogenesis, and precise regulation of retinoid levels during fetal gonad development provides the molecular control mechanism that specifies germ cell fate.
Sox18 induces development of the lymphatic vasculature in mice
TLDR
A critical role is demonstrated for Sox18 in developmental lymphangiogenesis, and new avenues to investigate for therapeutic management of human lymphangiopathies are suggested.
Sex determination and gonadal development in mammals.
TLDR
The growing body of knowledge relating to testis development and the beginnings of a picture of ovary development together illustrate the complex mechanisms by which these organ systems develop, inform the etiology, diagnosis, and management of disorders of sexual development, and help define what it is to be male or female.
The Wilms tumor suppressor WT1 regulates early gonad development by activation of Sf1.
TLDR
It is demonstrated here that WT1 and LHX9 function as direct activators of the Sf1 gene, and a pathway in which the products of the Wt1 and Lhx9 genes activate expression of S f1 and thus mediate early gonadogenesis is suggested.
SOX9 Regulates Prostaglandin D Synthase Gene Transcription in Vivo to Ensure Testis Development*
TLDR
The gene encoding prostaglandin D synthase (Pgds), the enzyme that produces PGD2, is expressed in Sertoli cells immediately after the onset of Sox9 expression, and chromatin immunoprecipitation proved that SOX9 but not SRY binds to the Pgds promoter in vivo.
Expression of distinct RNAs from 3′ untranslated regions
TLDR
Evidence is presented that large numbers of 3′UTRs in human, mouse and fly are also expressed separately from the associated protein-coding sequences to which they are normally linked, likely by post-transcriptional cleavage.
Signaling through the TGF Beta-Activin Receptors ALK4/5/7 Regulates Testis Formation and Male Germ Cell Development
TLDR
The strategy of inhibiting multiple Activin/NODAL/TGFβ receptors reduces the functional redundancy between these signaling pathways, thereby revealing new and essential roles for TGFβ and Activin signaling during testis formation and male germ cell development.
SOX8 Is Expressed during Testis Differentiation in Mice and Synergizes with SF1 to Activate the Amh Promoter in Vitro*
TLDR
In vitro assays showed that SOX8 binds specifically to SOX binding sites within the Amh minimal promoter and, likeSOX9, acts synergistically with SF1 through direct protein-protein interaction to enhance Amh expression, albeit at lower levels compared with SOX9.
Loss of Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) Reveals a Requirement for MAPK Signalling in Mouse Sex Determination
The boygirl (byg) mouse mutant reveals that MAP3K4-mediated signaling is necessary for normal SRY expression and testis specification in the developing mouse gonad.
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