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Preclinical evaluation of the cardiotoxicity of PK2: A novel HPMA copolymer–doxorubicin–galactosamine conjugate antitumour agent
In this study, PK2 displayed a ∼5-fold reduction in cardiotoxicity relative to free DOX and this supported the progression of PK2 into early clinical investigation. Expand
Modulation of normal tissue responses to radiation.
There is currently considerable interest in the possible modulation of normal tissue responses to radiation, to improve the therapeutic ratio in radiotherapy. Recent studies in pig skin haveExpand
Anticholinergic psychosis.
A case of anticholinergic psychossis in a 17-year-old male following suspected ingestion of an unknown amount of benztropine mesylate is discussed and the neuropsychiatric signs of and treatment for antICHolinergic psychosis are discussed. Expand
Repair, repopulation and cell cycle redistribution in rat foot skin.
The influence of the phenomena of the repair of sublethal damage, repopulation and the role of the reassortment of surviving clonogenic target cells within the cell cycle have been examined in the foot skin of rats using a series of split dose experiments to question the validity of a frequently made assumption of equal biological effect per fraction in a prolonged fractionated irradiation schedule. Expand
Modification of doxorubicin-induced cardiotoxicity: manipulation of the dosage schedule
Modification of the dosing schedule for doxorubicin (DOX) administration represents a possible method of reducing cardiotoxicity from this potent anti-cancer drug, while at the same time maintainingExpand
Modification of doxorubicin-induced cardiotoxicity: effect of essential fatty acids and ICRF-187 (dexrazoxane).
It was concluded that an oil containing GLA (So-1100) has similar cardioprotective properties against DOX-induced cardiotoxicity as ICRF-187, but with less general toxicity in this rat model. Expand
Clinical use of intravenous phenytoin sodium infusions.
Analysis of clinical data before and immediately after phenytoin infusions showed no statistically significant change in blood pressure and a small but significant drop in mean heart rate, and it was concluded that careful infusion of pheny toin sodium in 0.9% sodium chloride injection is safe. Expand
Trophic effects of essential fatty acids on pig skin
The daily oral administration of 3 ml of two oils (So‐5407 and So‐1129) containing essential fatty acids (EFAs) for 16 weeks resulted in a transient increase in cell proliferative activity in theExpand
Absorption of oral and intramuscular chlordiazepoxide by alcoholics
The active metabolite, N‐desmethylchlordiazepoxide, peaked significantly earlier with the oral dose than with the intramuscular dose after the patient was alcohol free for a week, and it is suggested this effect may be at least partially the result of the longer CDX half‐lives initially than a week later. Expand
The protective activity of ICRF-187 against doxorubicin-induced cardiotoxicity in the rat
The present findings may be interpreted as a true cardioprotection or a delay in the onset of the cardiotoxicity of doxorubicin resulting from pretreatment with the bisdioxopiperazine ICRF-187. Expand