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In vivo mapping of cholinergic terminals in normal aging, Alzheimer's disease, and Parkinson's disease
It is concluded that cholinergic neuron integrity can be monitored in living AD and PD patients, and that it is not so devastated in vivo as suggested by postmortem choline acetylransferase activity.
Synthesis and preliminary evaluation of carbon-11-meta-hydroxyephedrine: a false transmitter agent for heart neuronal imaging.
- K. Rosenspire, M. Haka, D. Wieland
- Chemistry, BiologyJournal of nuclear medicine : official…
- 1 August 1990
Preliminary results support this new tracer as a clinical agent for neuronal imaging of the heart with less than 5% metabolites in heart tissue 30 min after intravenous injection suggesting that [11C]meta-hydroxyephedrine is suitable for kinetic modeling.
Noninvasive evaluation of sympathetic nervous system in human heart by positron emission tomography.
[11C]hydroxyephedrine, in combination with dynamic PET imaging, allows the noninvasive delineation of myocardial adrenergic nerve terminals by positron emission tomography, which will provide insights into the effects of various disease processes on the neuronal integrity of the heart.
Assessment of cardiac sympathetic nerve integrity with positron emission tomography.
PET Imaging of human gliomas with ligands for the peripheral benzodiazepine binding site
It is concluded that the PK 11195 manifests greater binding than Ro5‐4864 to the peripheral‐type benzodiazepine binding site on human gliomas and that humangliomas can be successfully imaged using [11C]PK 11195 and PET.
In vivo mapping of cholinergic neurons in the human brain using SPECT and IBVM.
SPECT imaging of [123I]IBVM succeeds as an in vivo measure of cholinergic neuronal integrity and should be useful for the study of cerebral degenerative processes such as Alzheimer's disease.
Myocardial imaging with a radioiodinated norepinephrine storage analog.
Meta-iodobenzylguanidine (M-IBG), an iodinated aromatic analog of the hypotensive drug quanethidine, localizes in the heart of the rat, dog, and rhesus monkey and blocking studies with reserpine suggest that a major component of myocardial retention is sequestration within the norephinephrine storage vesicles of the adrenergic nerves.
Metaiodobenzylguanidine as an index of the adrenergic nervous system integrity and function.
- J. Sisson, D. Wieland, P. Sherman, T. Mangner, M. Tobes, S. Jacques
- Biology, ChemistryJournal of nuclear medicine : official…
- 1 October 1987
Although not a perfect analog of norepinephrine, [125I]MIBG appears to enter and leave the heart in patterns similar to those of [3H]NE, which gives indices of adrenergic neuron injury and function in the heart.
Evidence for regional catecholamine uptake and storage sites in the transplanted human heart by positron emission tomography.
- M. Schwaiger, G. Hutchins, D. Wieland
- Medicine, BiologyThe Journal of clinical investigation
- 1 May 1991
Data suggest the presence of neuronal tissue in the transplanted human heart, which may reflect regional sympathetic reinnervation, as well as the noninvasive delineation of sympathetic nerve terminals of the heart.
Metaiodobenzylguanidine to map scintigraphically the adrenergic nervous system in man.
- J. Sisson, B. Shapiro, W. Beierwaltes
- Biology, MedicineJournal of nuclear medicine : official…
- 1 October 1987
Metaiodobenzylguanidine (MIBG) localizes in adrenergic neurons; MIBG labeled with 123I then serves as an analog of norepinephrine, and concentrations of [123I]MIBG reflect sites of adrenergic neurons…