• Publications
  • Influence
Monitoring of implanted stem cell migration in vivo: A highly resolved in vivo magnetic resonance imaging investigation of experimental stroke in rat
In vivo monitoring of stem cells after grafting is essential for a better understanding of their migrational dynamics and differentiation processes and of their regeneration potential. Migration ofExpand
  • 711
  • 27
  • Open Access
A fully noninvasive and robust experimental protocol for longitudinal fMRI studies in the rat
tl;dr
We developed a new, totally noninvasive fMRI protocol, using sedation with the alpha2-adrenoreceptor agonist medetomidine in combination with transcutaneous monitoring of blood gases. Expand
  • 175
  • 25
  • Open Access
Differential Effects of NMDA and AMPA Glutamate Receptors on Functional Magnetic Resonance Imaging Signals and Evoked Neuronal Activity during Forepaw Stimulation of the Rat
Most of the currently used methods for functional brain imaging do not visualize neuronal activity directly but rather rely on the elicited hemodynamic and/or metabolic responses. Glutamate, theExpand
  • 67
  • 11
  • Open Access
Early Prediction of Functional Recovery after Experimental Stroke: Functional Magnetic Resonance Imaging, Electrophysiology, and Behavioral Testing in Rats
Therapeutic success of treatment of cerebral diseases must be assessed in terms of functional outcome. In experimental stroke studies, this has been limited to behavioral studies combined withExpand
  • 99
  • 10
  • Open Access
Reliability and spatial specificity of rat brain sensorimotor functional connectivity networks are superior under sedation compared with general anesthesia
Functional connectivity networks derived from resting‐state functional MRI (rsfMRI) have received increasing interest to further our understanding of brain function. The anesthesia in rodent modelsExpand
  • 57
  • 10
Functional connectivity in the rat at 11.7T: Impact of physiological noise in resting state fMRI
tl;dr
We investigate the contribution of physiological noise and its impact on assessment of functional connectivity in rs-fMRI of medetomidine sedated, spontaneously breathing rats at ultrahigh field of 11.7 Tesla. Expand
  • 86
  • 7
Kinetics of phenylalanine transport at the human blood–brain barrier investigated in vivo
In vivo proton magnetic resonance spectroscopy was used to investigate intracerebral phenylalanine (Phe) concentrations in nine patients with classical phenylketonuria (PKU). The study includedExpand
  • 46
  • 6
T1 effects of a bolus-injectable superparamagnetic iron oxide, SH U 555 A: dependence on field strength and plasma concentration--preliminary clinical experience with dynamic T1-weighted MR imaging.
PURPOSE To investigate the field strength dependency of relaxivity values with SH U 555 A, concentration-dependent T1 effects, and findings at dynamic T1-weighted magnetic resonance (MR) imaging inExpand
  • 63
  • 5
Individual blood–brain barrier phenylalanine transport determines clinical outcome in phenylketonuria
Different clinical outcomes in spite of comparable dietary controls are well known in patients with phenylketonuria. Currently, reasons for this phenomenon are unknown. Kinetic investigations in 15Expand
  • 91
  • 5
Central nervous system inflammatory response after cerebral infarction as detected by magnetic resonance imaging
Brain inflammation contributes to the tissue injury caused by ischemic stroke. Macrophages as the most abundant inflammatory cell population in stroke lesions can be visualized using ultrasmallExpand
  • 81
  • 4