Share This Author
Drosophila odorant receptors are both ligand-gated and cyclic-nucleotide-activated cation channels
It is shown that application of odorants to mammalian cells co-expressing Or22a and Or83b results in non-selective cation currents activated by means of an ionotropic and a metabotropic pathway, and a subsequent increase in the intracellular Ca2+ concentration.
A Conserved Dedicated Olfactory Circuit for Detecting Harmful Microbes in Drosophila
Antennal transcriptome of Manduca sexta
- E. Grosse-Wilde, L. S. Kuebler, Sascha Bucks, H. Vogel, D. Wicher, B. Hansson
- BiologyProceedings of the National Academy of Sciences
- 15 April 2011
The use of transcriptomic and microarray data is presented to identify members of the main olfactory gene families of Manduca sexta and compares the expression of the near-complete transcript sets in male and female antennae.
Non-synaptic ion channels in insects — basic properties of currents and their modulation in neurons and skeletal muscles
Physiological and morphological characterization of local interneurons in the Drosophila antennal lobe.
This study provides a systematic characterization of olfactory LNs in Drosophila and demonstrates that a variety of inhibitory LNs, characterized by class-specific electrophysiological and morphological properties, construct the neural circuit of the AL.
Differential receptor activation by cockroach adipokinetic hormones produces differential effects on ion currents, neuronal activity, and locomotion.
It is shown that AKHs act through the same basic mechanisms on neuronal and nonneuronal cells, and they support an integration of metabolic and neuronal effects in homoeostatic mechanisms.
Four novel sequences in Drosophila melanogaster homologous to the auxiliary Para sodium channel subunit TipE.
Ca2+ currents in central insect neurons: electrophysiological and pharmacological properties.
The dihydropyridine insensitivity of the phenylalkylamine-sensitive HVA currents is a property the cockroach DUM cells share with other invertebrate neurons.
Phosphorylation via PKC Regulates the Function of the Drosophila Odorant Co-Receptor
- V. Sargsyan, M. N. Getahun, Sofía Lavista Llanos, S. Olsson, B. Hansson, D. Wicher
- BiologyFront. Cell. Neurosci.
- 30 March 2011
It is concluded that metabotropic pathways affecting the phosphorylation state of Orco regulate OR function and thereby shape the OSN odor response.
Insect Odorant Response Sensitivity Is Tuned by Metabotropically Autoregulated Olfactory Receptors
The results indicate that Orco-mediated regulation of OR sensitivity provides tunable ionotropic receptors capable of detecting odors over a wider range of concentrations, providing broadened sensitivity over IRs themselves.