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Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up the top associationExpand
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The Growing Burden of Invasive Melanoma: Projections of Incidence Rates and Numbers of New Cases in Six Susceptible Populations through 2031.
New melanoma therapies are being developed rapidly, complementing prevention and detection strategies for disease control. Estimating the future burden of melanoma is necessary for deciding how bestExpand
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Childhood sun exposure as a risk factor for melanoma: a systematic review of epidemiologic studies
AbstractObjective: To review the evidence that childhood is a period of particular susceptibility to the carcinogenic effects of solar radiation. Methods: Studies were identified through searches ofExpand
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Combined effects of obesity, acid reflux and smoking on the risk of adenocarcinomas of the oesophagus
Objective: To measure the relative risks of adenocarcinomas of the oesophagus and gastro-oesophageal junction associated with measures of obesity, and their interactions with age, sex,Expand
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Common sequence variants on 20q11.22 confer melanoma susceptibility
We conducted a genome-wide association pooling study for cutaneous melanoma and performed validation in samples totaling 2,019 cases and 2,105 controls. Using pooling, we identified a new melanomaExpand
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Cigarette smoking and adenocarcinomas of the esophagus and esophagogastric junction: a pooled analysis from the international BEACON consortium.
BACKGROUND Previous studies that showed an association between smoking and adenocarcinomas of the esophagus and esophagogastric junction were limited in their ability to assess differences by tumorExpand
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A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma
So far, two genes associated with familial melanoma have been identified, accounting for a minority of genetic risk in families. Mutations in CDKN2A account for approximately 40% of familial cases,Expand
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Effectiveness of quadrivalent human papillomavirus vaccine for the prevention of cervical abnormalities: case-control study nested within a population based screening programme in Australia
Objective To measure the effectiveness of the quadrivalent human papillomavirus (HPV) vaccine against cervical abnormalities four years after implementation of a nationally funded vaccinationExpand
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Melanocytic nevi, solar keratoses, and divergent pathways to cutaneous melanoma.
BACKGROUND Some melanomas form on sun-exposed body sites, whereas others do not. We previously proposed that melanomas at different body sites arise through different pathways that have differentExpand
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Genome-wide association study identifies three new melanoma susceptibility loci
We report a genome-wide association study for melanoma that was conducted by the GenoMEL Consortium. Our discovery phase included 2,981 individuals with melanoma and 1,982 study-specific controlExpand
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