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Molecular Basis of Lysosomal Enzyme Recognition: Three-Dimensional Structure of the Cation-Dependent Mannose 6-Phosphate Receptor
TLDR
The three-dimensional structure of a glycosylation-deficient, yet fully functional form of the extracytoplasmic domain of the bovine CD-MPR complexed with mannose 6-phosphate at 1.8 A resolution is reported. Expand
Nickel-catalyzed, sodium iodide-promoted reductive dimerization of alkyl halides, alkyl pseudohalides, and allylic acetates.
The first general method for the reductive dimerization of alkyl halides, alkyl mesylates, alkyl trifluoroacetates, and allylic acetates is reported which proceeds with low catalyst loading (0.5 to 5Expand
[5]HELOL Phosphite: A Helically Grooved Sensor of Remote Chirality
Even when the first center of chirality is far from a functional group, the stereochemistries of chiral molecules can be sensed if the functional group is attached to a phosphorus embedded within theExpand
Nickel-catalyzed reductive cross-coupling of aryl halides with alkyl halides.
TLDR
The reaction appears to avoid the formation of intermediate organomanganese species, and a synergistic effect was found when a mixture of two ligands was employed. Expand
Diastereoselective and enantioselective Rh(I)-catalyzed additions of arylboronic acids to N-tert-butanesulfinyl and N-diphenylphosphinoyl aldimines.
Two new Rh(I)-catalyzed methods for the synthesis of chiral alpha-branched amines via addition of arylboronic acids to N-tert-butanesulfinyl and N-diphenylphosphinoyl imines have been developed. TheExpand
Improved synthesis of tert-butanesulfinamide suitable for large-scale production.
TLDR
An improved synthesis of tert-butanesulfinamide that overcomes the scalability problems of the previous syntheses is described and utilizes an inexpensive chiral ligand prepared in a single step from commercially available cis-1-amino-indan-2-ol. Expand
Multimetallic Ni- and Pd-Catalyzed Cross-Electrophile Coupling To Form Highly Substituted 1,3-Dienes.
TLDR
The synthesis of highly substituted 1,3-dienes from the coupling of vinyl bromides with vinyl triflates is reported for the first time and appears to proceed by an unusual zinc-mediated transfer of a vinyl group between the nickel and palladium centers. Expand
Easy Synthesis of Functionalized Hetero[7]helicenes.
Hetero[7]helicenebisquinones can be synthesized easily on a multigram scale by combining the silyl enol ethers of 3,6-diacetyldibenzofuran, 3,6-diacetyldibenzothiophene, and 3,6-diacetylcarbazoleExpand
Mechanism and selectivity in nickel-catalyzed cross-electrophile coupling of aryl halides with alkyl halides.
TLDR
Light is shed on the mechanism for the nickel-catalyzed cross-electrophile coupling of aryl halide with alkyl halides and it is demonstrated that the selectivity arises from an unusual catalytic cycle that combines both polar and radical steps to form the new C-C bond. Expand
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