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Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets
Droplet Barcoding for Single-Cell Transcriptomics Applied to Embryonic Stem Cells
Physical forces during collective cell migration
These unexpected findings demonstrate that although the leader cell may have a pivotal role in local cell guidance, physical forces that it generates are but a small part of a global tug-of-war involving cells well back from the leading edge.
Geometrically mediated breakup of drops in microfluidic devices.
Two methods for passively breaking larger drops into precisely controlled daughter drops using pressure-driven flow in simple microfluidic configurations using a T junction and flow past isolated obstacles are demonstrated.
Collective cell guidance by cooperative intercellular forces
Migrations of both endothelial and epithelial monolayers conform to this behavior, as do breast cancer cell lines before but not after the epithelial-mesenchymal transition, and collective migration in these diverse systems is seen to be governed by a simple but unifying physiological principle.
Elastic Behavior of Cross-Linked and Bundled Actin Networks
It is shown that networks of cross-linked and bundled actin filaments exhibit exceptional elastic behavior that reflects the mechanical properties of individual filaments, and parameterize the full range of behavior in a state diagram and elucidate its origin with a robust model.
Monodisperse Double Emulsions Generated from a Microcapillary Device
It is shown that the droplet size can be quantitatively predicted from the flow profiles of the fluids, which makes this a flexible and promising technique.
Massively-parallel single nucleus RNA-seq with DroNc-seq
DroNc-seq is developed: massively parallel sNuc-seq with droplet technology that profiles 39,111 nuclei from mouse and human archived brain samples to demonstrate sensitive, efficient, and unbiased classification of cell types, paving the way for systematic charting of cell atlases.
Single-cell ChIP-seq reveals cell subpopulations defined by chromatin state
The method for single-cell analysis reveals aspects of epigenetic heterogeneity not captured by transcriptional analysis alone, and identifies a spectrum of subpopulations defined by differences in chromatin signatures of pluripotency and differentiation priming.
Eutectic Gallium‐Indium (EGaIn): A Liquid Metal Alloy for the Formation of Stable Structures in Microchannels at Room Temperature
This paper describes the rheological behavior of the liquid metal eutectic gallium‐indium (EGaIn) as it is injected into microfluidic channels to form stable microstructures of liquid metal. EGaIn is…