Folate levels and neural tube defects. Implications for prevention.
Using data from a recent case-control study, a woman's risk of having a child with a neural tube defect (NTD) was found to be associated with early pregnancy red cell folate levels in a continuous…
Maternal plasma folate and vitamin B12 are independent risk factors for neural tube defects.
- P. Kirke, A. Molloy, L. Daly, H. Burke, D. Weir, J. Scott
- Medicine, BiologyThe Quarterly journal of medicine
- 1 November 1993
Plasma folate and plasma B12 were independent risk factors for NTDs, suggesting that the enzyme methionine synthase is involved directly or indirectly in the aetiology.
Homocysteine metabolism in pregnancies complicated by neural-tube defects
Randomized trial of folic acid supplementation and serum homocysteine levels.
A dosage of folic acid of 0.8 mg/d appears necessary to achieve the maximum reduction in serum homocysteine level across the range of homocy steine levels in the population, indicating that monitoring of the reduction in an individual is impractical.
A genetic defect in 5,10 methylenetetrahydrofolate reductase in neural tube defects.
- A. Whitehead, P. Gallagher, J. Scott
- MedicineQJM : monthly journal of the Association of…
- 1 November 1995
Genetic screening could identify women who will require folic acid supplements to reduce their risk of having a child with an NTD, and explains the association between some NTDs and elevated homocysteine, given that the reductase is important in homocy steine metabolism.
Minimum effective dose of folic acid for food fortification to prevent neural-tube defects
Unmetabolized folic acid in serum: acute studies in subjects consuming fortified food and supplements.
- P. Kelly, J. Mcpartlin, M. Goggins, D. Weir, J. Scott
- MedicineAmerican Journal of Clinical Nutrition
- 1 June 1997
A repeated serum folic acid response is likely to be found in many women complying with the advice to take 400 micrograms folic Acid/d to prevent the occurrence of neural tube defects, particularly in consumers in nontargeted populations of large amounts of fortified foods.
Increased prevalence of methylenetetrahydrofolate reductase C677T variant in patients with inflammatory bowel disease, and its clinical implications
There is an association between the thermolabile MTHFR C677T variant and IBD, which accounts in part for the raised plasma tHcy found in patients with IBD and may contribute to the increased incidence of thromboembolic complications.
The "thermolabile" variant of methylenetetrahydrofolate reductase and neural tube defects: An evaluation of genetic risk and the relative importance of the genotypes of the embryo and the mother.
A biological model of MTHFR-related NTD pathogenesis is favored, in which suboptimal maternal folate status imposes biochemical stress on the developing embryo, a stress it is ill-equipped to tolerate if it has a TT genotype.
Increased incidence of non-Hodgkin's lymphoma in inflammatory bowel disease patients on immunosuppressive therapy but overall risk is low
Although underlying IBD may be a causal factor in the development of intestinal NHL, the experience suggests that immunosuppressive drugs can significantly increase the risk of NHL in IBD.