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Darwinian Evolution Can Follow Only Very Few Mutational Paths to Fitter Proteins
It is demonstrated that 102 mutational trajectories linking β-lactamase alleles are inaccessible to Darwinian selection and that many of the remaining trajectories have negligible probabilities of realization, which implies that the protein tape of life may be largely reproducible and even predictable.
Missense meanderings in sequence space: a biophysical view of protein evolution
This work reviews the literature on biophysics as it relates to molecular evolution and advances a biophysical model of protein evolution that helps to understand phenomena that range from the dynamics of molecular adaptation to the clock-like rate ofprotein evolution.
PERSPECTIVE:SIGN EPISTASIS AND GENETIC CONSTRAINT ON EVOLUTIONARY TRAJECTORIES
The theoretical and empirical considerations imply that strong genetic constraint on the selective accessibility of trajectories to high fitness genotypes may exist and suggest specific areas of investigation for future research.
Subtypes of vagal afferent C‐fibres in guinea‐pig lungs
- B. Undem, B. Chuaychoo, M-G Lee, D. Weinreich, A. Myers, M. Kollarik
- BiologyThe Journal of physiology
- 1 May 2004
The data support the hypothesis that both neural crest‐derived neurones (jugular ganglia) and placode‐derived neuronones (nodose ganglia), which are derived from cell bodies situated in two distinct vagal sensory ganglia, project C‐fibres in the vagus, and that these two C-fibre populations represent distinct phenotypes.
Empirical fitness landscapes reveal accessible evolutionary paths
This work presents the first view on empirical evolutionary landscapes, which can be reconstructed in the laboratory, and asks why particular evolutionary paths are taken.
Stepwise acquisition of pyrimethamine resistance in the malaria parasite
- Elena R. Lozovsky, Thanat Chookajorn, D. Hartl
- BiologyProceedings of the National Academy of Sciences
- 21 July 2009
The predicted favored pathways of drug resistance are consistent with those reported in previous kinetic studies, as well as DHFR polymorphisms observed in natural populations, and suggest an explanation for why I164L is detected in Southeast Asia and South America, but not in Africa.
Redistribution of NaV1.8 in Uninjured Axons Enables Neuropathic Pain
Observations suggest that aberrant activity in uninjured C-fibers is a necessary component of pain associated with partial nerve injury and suggest that blocking NaV1.8 would be an effective treatment of neuropathic pain.
Should evolutionary geneticists worry about higher-order epistasis?
Patterns and mechanisms of genetic and phenotypic differentiation in marine microbes
- M. Polz, D. Hunt, S. Preheim, D. Weinreich
- Biology, Environmental SciencePhilosophical Transactions of the Royal Society B…
- 29 November 2006
It is suggested that ocean bacteria follow at least two different adaptive strategies, which constrain rates and bounds of evolutionary processes: the ‘opportuni-troph’, exploiting spatially and temporally variable resources and the passive oligotroph, efficiently using low nutrient concentrations.