Antibacterial agents based on the cyclic d,l-α-peptide architecture
- S. Fernández-López, H. Kim, M. Ghadiri
- BiologyNature
- 26 July 2001
It is reported that six- and eight-residue cyclic d,l-α-peptides act preferentially on Gram-positive and/or Gram-negative bacterial membranes compared to mammalian cells, increase membrane permeability, collapse transmembrane ion potentials, and cause rapid cell death.
Antibacterial agents based on the cyclic D,L-alpha-peptide architecture.
- S. Fernández-López, H. Kim, M. Ghadiri
- BiologyNature
- 2001
It is reported that six- and eight-residue cyclic d,l-alpha-peptides act preferentially on Gram-positive and/or Gram-negative bacterial membranes compared to mammalian cells, increase membrane permeability, collapse transmembrane ion potentials, and cause rapid cell death.
Systemic Antibacterial Activity of Novel Synthetic Cyclic Peptides
- V. Dartois, J. Sánchez-Quesada, T. Parr
- Biology, MedicineAntimicrobial Agents and Chemotherapy
- 1 August 2005
The results suggest that these amphipathic cyclic d,l-α-peptides have potential for systemic administration and treatment of otherwise antibiotic-resistant infections.
Combinatorial generation and analysis of nanometer- and micrometer-scale silicon features via `dip-pen' nanolithography and wet chemical etching
- D. Weinberger, Seunghun Hong, C. Mirkin, B. Wessels, T. B. Higgins
- Materials Science
- 1 November 2000
The Transition Metal Coordination Chemistry of Hemilabile Ligands
- C. Slone, D. Weinberger, C. Mirkin
- Chemistry
- 9 March 2007
Biomimetic catalysis of intermodular aminoacyl transfer.
- K. Wilcoxen, L. Leman, D. Weinberger, Zheng-zheng Huang, M. Ghadiri
- Chemistry, BiologyJournal of the American Chemical Society
- 31 January 2007
The design and functional characterizations of short synthetic α-helical peptides that mimic the aminoacyl loading and intermodular aminoacyL transfer steps of NRPS with aminolysis rate enhancements in neutral aqueous solutions of up to 5400-fold are reported.
Terthienyl and poly-terthienyl ligands as redox-switchable hemilabile ligands for oxidation-state-dependent molecular uptake and release.
- D. Weinberger, T. B. Higgins, C. Mirkin, C. Stern, L. Liable-Sands, A. Rheingold
- ChemistryJournal of the American Chemical Society
- 21 February 2001
FT-IR spectroelectrochemical experiments on 4a indicate that terthienyl-based oxidation removes electron density from the metal center, equivalent to approximately 11-17% of the electronic change that occurs upon direct oxidation of Ru(II) to Ru(III) in analogous complexes.
Functional and mechanistic analyses of biomimetic aminoacyl transfer reactions in de novo designed coiled coil peptides via rational active site engineering.
- L. Leman, D. Weinberger, Zheng-zheng Huang, K. Wilcoxen, M. Ghadiri
- Biology, ChemistryJournal of the American Chemical Society
- 16 February 2007
These studies demonstrate the feasibility of engineering efficient de novo peptide sequences possessing active sites and functions reminiscent of those in natural enzymes as well as significantly influenced by engineering changes in the active site microenvironment through amino acid substitutions and variations in the inter-residue distances and geometry.
correction: Antibacterial agents based on the cyclic d,l-α-peptide architecture
- S. Fernández-López, H. Kim, M. Ghadiri
- BiologyNature
- 15 November 2001
This corrects the article DOI: 35086601
Multispecies Evaluation of a Long-Acting Tenofovir Alafenamide Subdermal Implant for HIV Prophylaxis
- M. Gunawardana, Mariana Remedios-Chan, M. Baum
- Biology, MedicineFrontiers in Pharmacology
- 25 November 2020
A subdermal implant delivering the potent ARV drug tenofovir alafenamide is developed that could provide protection from HIV-1 infection for 6 months, or longer, and both animal models were shown to hold significant promise in LA product development.
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