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ANTAGONISM OF ADENOSINE 5′‐TRIPHOSPHATE‐INDUCED RELAXATION BY 2‐2′‐PYRIDYLISATOGEN IN THE TAENIA OF GUINEA‐PIG CAECUM
1 2‐2′Pyridylisatogen tosylate (PIT) (>2.5 μM) relaxed the guinea‐pig isolated taenia caeci by an unknown mechanism. 2 With higher concentrations of PIT (>12.5 μM) subsequent applications ofExpand
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THE MECHANISM OF THE RELAXANT EFFECT OF 2‐2′‐PYRIDYLISATOGEN ON THE ISOLATED TAENIA OF THE GUINEA‐PIG CAECUM
1 2‐2′‐Pyridylisatogen tosylate (PIT) slowly relaxed taenia caeci preparations of the guinea‐pig in a concentration‐dependent manner (threshold 2.5 μm). The relaxant effect did not showExpand
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Realistic estimations of kinetic constants for the oxidation of naturally occurring monoamines by monoamine oxidase.
Abstract A sensitive and convenient assay for the determination of kinetic constants for MAO is described. Five naturally occurring substrates—tyramine, tryptamine, dopamine, 5-hydroxytryptamine, andExpand
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IDENTIFICATION OF SEPARATE RECEPTORS FOR ADENOSINE AND ADENOSINE 5′‐TRIPHOSPHATE IN CAUSING RELAXATIONS OF THE ISOLATED TAENIA OF THE GUINEA‐PIG CAECUM
1 The mechanisms by which adenosine 5′‐triphosphate (ATP), adenosine 5′‐diphosphate (ADP), adenosine 5′‐monophosphate (AMP) and adenosine relax the taenia caecum preparation of the guinea‐pig haveExpand
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AN INDIRECT SYMPATHOMIMETIC EFFECT OF BURIMAMIDE ON KITTEN ISOLATED ATRIA
1 Burimamide (34‐1080 μM) caused a concentration‐dependent increase in the force and frequency of contraction of kitten isolated atria. 2 Metiamide (467 μM) had no stimulant action on kitten atriaExpand
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The effect of eserine on the response of the vas deferens to hypogastric nerve stimulation.
  • J. H. Burn, D. Weetman
  • Chemistry, Medicine
  • British journal of pharmacology and chemotherapy
  • 1 February 1963
In experiments in which the vas deferens together with the hypogastric nerve of the guinea-pig was studied as an isolated preparation, the relation between frequency of electrical stimulation of theExpand
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ANTAGONISM OF THE INHIBITORY EFFECTS OF ADENOSINE 5′‐TRIPHOSPHATE ON THE ISOLATED TAENIA OF THE GUINEA‐PIG CAECUM: STRUCTURE‐ACTIVITY RELATIONSHIPS WITHIN A SERIES OF ISATOGEN DERIVATIVES
1 A series of eight isatogen derivatives was studied on isolated tissues taken from guinea‐pigs. The ability of the compounds to relax the taenia, to inhibit adenosine 5′‐diphosphate (ADP)‐stimulatedExpand
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THE EXISTENCE OF A NEW SUBTYPE OF α‐ADRENOCEPTOR ON THE RAT ANOCOCCYGEUS IS REVEALED BY SGD 101/75 AND PHENOXYBENZAMINE
1 Noradrenaline and Sgd 101/75 (4(2‐imidazoline‐amino)‐2‐methylindazol‐chlorhydrate) acted as full agonists in contracting the rat anococcygeus. 2 Very low concentrations of phenoxybenzamine (0.3 nmExpand
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The effects of ATP-receptor blocking agents on the response to the guinea-pig isolated bladder preparation to hyoscine-resistant nerve stimulation.
  • D. Weetman, N. Turner
  • Chemistry, Medicine
  • Archives internationales de pharmacodynamie et de…
  • 1 July 1977
The effects of very high concentrations of quinidine, imidazole and phentolamine were investigated on the responses of the guinea-pig isolated bladder to nerve stimulation in the presence of hyoscineExpand
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The problems associated with the use of 2,2′‐pyridylisatogen tosylate in evaluating the allegedly purinergic innervation of peripheral organs
As can be seen from Table 1 , the dose response is 36 % greater with the suggested carbonate/bicarbonate buffer than with the phosphate buffer recommended in the B.P. It was thought that this mightExpand
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