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Enhanced Dissociation of HLA-DR-Bound Peptides in the Presence of HLA-DM
Human leukocyte antigen (HLA)-DM is a critical participant in antigen presentation that catalyzes the release of class II-associated invariant chain-derived peptides (CLIP) from newly synthesized… Expand
Analysis of HLA-E Peptide-Binding Specificity and Contact Residues in Bound Peptide Required for Recognition by CD94/NKG2 1
- J. Miller, D. Weber, C. Ibegbu, J. Pohl, J. Altman, P. Jensen
- Biology, Medicine
- The Journal of Immunology
- 1 August 2003
The MHC class Ib molecule HLA-E is the primary ligand for CD94/NKG2A-inhibitory receptors expressed on NK cells, and there is also evidence for TCR-mediated recognition of this molecule. HLA-E… Expand
Regulated Expression of Human Histocompatibility Leukocyte Antigen (HLA)-DO During Antigen-dependent and Antigen-independent Phases of B Cell Development
- X. Chen, O. Laur, +5 authors P. Jensen
- Medicine, Biology
- The Journal of experimental medicine
- 15 April 2002
Human histocompatibility leukocyte antigen (HLA)-DO, a lysosomal resident major histocompatibility complex class II molecule expressed in B cells, has previously been shown to be a negative regulator… Expand
DM enhances peptide binding to class II MHC by release of invariant chain-derived peptide.
Major histocompatibility complex (MHC) class II molecules bind antigenic peptides rapidly after biosynthesis in antigen-presenting cells (APCs). By contrast, the rate of peptide binding to purified… Expand
Guanylate-binding protein-1 is expressed at tight junctions of intestinal epithelial cells in response to interferon-γ and regulates barrier function through effects on apoptosis
Guanylate-binding protein-1 (GBP-1) is an interferon inducible large GTPase involved in endothelial cell proliferation and invasion. In this report, expression and function of GBP-1 were investigated… Expand
Positive selection of a Qa-1-restricted T cell receptor with specificity for insulin.
The phenotype and development of T cells from transgenic mice expressing a T cell receptor with specificity for insulin presented by the MHC class Ib molecule Qa-1(b) was investigated. Peripheral T… Expand
Effects of phenol on barrier function of a human intestinal epithelial cell line correlate with altered tight junction protein localization.
- I. McCall, A. Betanzos, D. Weber, P. Nava, G. Miller, C. Parkos
- Medicine, Chemistry
- Toxicology and applied pharmacology
- 15 November 2009
Phenol contamination of soil and water has raised concerns among people living near phenol-producing factories and hazardous waste sites containing the chemical. Phenol, particularly in high… Expand
Inefficient peptide binding by cell-surface class II MHC molecules.
- M. Sherman, D. Weber, E. Spotts, J. C. Moore, P. Jensen
- Medicine, Biology
- Cellular immunology
- 25 November 1997
The efficiency of peptide loading onto surface class II MHC molecules in intact APC was investigated, using a previously defined europium immunoassay as well as a simplified Western blot procedure.… Expand
Novel structural determinants on SIRP alpha that mediate binding to CD47.
Signal regulatory proteins (SIRP-alpha, -beta, and -gamma) are important regulators of several innate immune functions that include leukocyte migration. Membrane distal (D1) domains of SIRPalpha and… Expand
Contribution de la photogrammetrie numerique a l'etude spatio-temporelle de versants instables; l'exemple du glissement de terrain de Super-Sauze (Alpes-de-Haute-Provence, France)
Recent developments in image processing and digital photogrammetry offer to the geomorphologists increasingly accessible and effective tools for the spatio-temporal knowledge of landslides. These… Expand