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Coordination of circadian timing in mammals
TLDR
Circadian rhythms are generated by one of the most ubiquitous and well-studied timing systems and are tamed by a master clock in the brain, which coordinates tissue-specific rhythms according to light input it receives from the outside world.
Molecular analysis of mammalian circadian rhythms.
TLDR
Greater understanding of the cellular and molecular mechanisms of the SCN clockwork provides opportunities for pharmacological manipulation of circadian timing.
Interacting molecular loops in the mammalian circadian clock.
TLDR
Analysis of Clock/Clock mutant mice, homozygous Period2(Brdm1) mutants, and Cryptochrome-deficient mice reveals substantially altered Bmal1 rhythms, consistent with a dominant role of PERIOD2 in the positive regulation of the Bmal 1 loop.
Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor.
TLDR
The Mel1b melatonin receptor may mediate the reported actions of melatonin in retina and participate in some of the neurobiological effects ofmelatonin in mammals.
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