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K562 human leukaemic cells synthesise embryonic haemoglobin in response to haemin
STUDIES of the regulation of human erythropoiesis and haemoglobin synthesis at different phases of development are hampered by the lack of a self-sustaining culture in which erythroid differentiationExpand
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Cellular mechanism for the protective effect of haemoglobin S against P. falciparum malaria
RELATIVE protection against Plasmodium falciparum malaria afforded to heterozygous carriers of the sickle-cell gene is now the accepted mechanism for the high frequency of the gene in areas whereExpand
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Haemoglobin Constant Spring—A Chain Termination Mutant ?
Haemoglobin Constant Spring is an unusual variant which comprises only 1–2% of the total haemoglobin in heterozygotes. It has α-chains which are 172 residues long instead of the normal 141, and whenExpand
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Globin Synthesis in Thalassaemia: An in vitro Study
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Effects of foetal haemoglobin on susceptibility of red cells to Plasmodium falciparum
HIGH gene frequencies for the sickling disorders and β thalassaemia may be due to the relative protection against Plasmodium falciparum malaria which has been afforded to heterozygous carriers1. InExpand
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Switch from foetal to adult haemoglobin synthesis in normal and hypophysectomised sheep
DURING the normal human perinatal period foetal haemoglobin (Hb F; α2γ2) is replaced by the major and minor adult haemoglobins, Hbs A (α2β2) and A2 (α2δ2) respectively1,2. Little is known about theExpand
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Foetal erythropoiesis in human leukaemia
DURING human development changes occur in the red-cell proteins and antigens1. At birth the predominant haemoglobin (Hb) is Hb F with approximately 20% and less than 1% of the major and minor adultExpand
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High fetal hemoglobin production in sickle cell anemia in the eastern province of Saudi Arabia is genetically determined.
Homozygous sickle cell disease in the eastern province of Saudi Arabia is clinically mild. Circulating fetal hemoglobin levels of 16.0 +/- 7.4% were found in these anemic patients, but only 1.09 +/-Expand
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The frequency and origin of the sickle cell mutation in the district of Coruche/Portugal
SummaryThe frequency of the βs mutation in the district of Coruche/Portugal is estimated to be about 4% from analysis of a group of 181 school children and their teachers in an area in which malariaExpand
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An Improved Method for the Characterization of Human Haemoglobin Mutants: Identification of α2β295GLU, Haemoglobin N (Baltimore)
An Improved Method for the Characterization of Human Haemoglobin Mutants: Identification of α2β295GLU, Haemoglobin N (Baltimore)
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