• Publications
  • Influence
Paleoenvironmental implications of novel C30 steranes in Precambrian to Cenozoic Age petroleum and bitumen
Petroleums and bitumens from Early Proterozoic (≈ 1800 Ma) to Miocene (≈ 15 Ma) age marine strata contain 24-isopropylcholestanes, a novel group of C30 steroids. The abundance of these compounds,Expand
Rearranged hopanes in sediments and petroleum
Abstract Two new rearranged hopanoid hydrocarbons have been isolated from a Prudhoe Bay crude, Alaska. 17α(H)-15α-methyl-27-norhopane was determined by X-ray crystallography. It is the firstExpand
Biodegradation of acyclic isoprenoids by Pseudomonas species.
The ability of various pseudomonads to utilize acyclic isoprenoids as a sole carbon source was investigated and geraniol utilization as a taxonomic indicator for different subgroups of pseudomonADs is discussed. Expand
Identification of unique mechanisms for triterpene biosynthesis in Botryococcus braunii
These findings were unexpected because squalene synthase, an ancient and likely progenitor to the other Botryococcus triterpene synthases, catalyzes a two-step reaction within a single enzyme unit without intermediate release, yet in B. braunii, these activities appear to have separated and evolved interdependently for specialized triterPene oil production greater than 500 MYA. Expand
Chemostratigraphic reconstruction of biofacies: Molecular evidence linking cyst-forming dinoflagellates with pre-Triassic ancestors
New data from numerous detailed mass-spectrometric studies have detected triaromatic dinosteroids in Precambrian to Cenozoic rock samples. Triaromatic dinosteroids are organic geochemicals derivedExpand
Microbial growth on hydrocarbons: terminal branching inhibits biodegradation.
This microbial sampling dramatically illustrated the deleterious effect of alkyl branching, especially anteiso-terminal branching, on the biodegradation of hydrocarbons. Expand
Functional Identification of Valerena-1,10-diene Synthase, a Terpene Synthase Catalyzing a Unique Chemical Cascade in the Biosynthesis of Biologically Active Sesquiterpenes in Valeriana officinalis*
The catalytic mechanism for VoTPS1 is investigated and evidence for the involvement of a caryophyllenyl carbocation, a cyclobutyl intermediate, in the biosynthesis of valerena-1,10-diene is reported. Expand
Analysis and occurrence of C26-steranes in petroleum and source rocks
Abstract The C26-steranes previously reported in oils and source rocks (MOLDOWAN et al., 1985) have been identified as 21-, 24-, and 27-norcholestanes (1A, 1B, and 1C). Various 24-norcholesterols orExpand
The interaction of divalent metal ions with tris buffer in dilute solution.
Abstract The interaction of 2-amino-2-(hydroxymethyl)-1,3-propanediol (tris) with eight divalent metal ions has been investigated under conditions commonly employed in biochemical studies. FormationExpand
Fluorinated N,N-dialkylaminostilbenes repress colon cancer by targeting methionine S-adenosyltransferase 2A.
A family of fluorinated N,N-dialkylaminostilbene agents that inhibit the proliferation of CRC cells in vitro and in vivo are developed and suggest that FIDAS analogues targeting MAT2A represent a family of novel and potentially useful agents for cancer treatment. Expand