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Automated generation and evaluation of specific MHC binding predictive tools: ARB matrix applications
Prediction of which peptides can bind major histocompatibility complex (MHC) molecules is commonly used to assist in the identification of T cell epitopes. However, because of the large numbers ofExpand
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HIV and SIV CTL escape: implications for vaccine design
Cytotoxic T lymphocytes (CTLs) have a central role in the successful control of immunodeficiency virus infection. Evasion of this immune response through CTL escape is therefore an important factorExpand
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Impact of MHC class I diversity on immune control of immunodeficiency virus replication
The recent failure of the T-cell-based HIV vaccine trial led by Merck &Co., Inc. prompts the urgent need to refocus on the question of which T-cell responses are required to control HIV replication.Expand
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Mamu-B*08-Positive Macaques Control Simian Immunodeficiency Virus Replication
ABSTRACT Certain major histocompatibility complex (MHC) class I alleles are associated with the control of human immunodeficiency virus and simian immunodeficiency virus (SIV) replication. We haveExpand
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Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia
Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infections are characterized by early peaks of viraemia that decline as strong cellular immune responses develop. AlthoughExpand
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Reversion of CTL escape–variant immunodeficiency viruses in vivo
Engendering cytotoxic T-lymphocyte (CTL) responses is likely to be an important goal of HIV vaccines. However, CTLs select for viral variants that escape immune detection. Maintenance of such escapeExpand
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Premature induction of an immunosuppressive regulatory T cell response during acute simian immunodeficiency virus infection.
Here we report the results of an investigation into the possibility that one mechanism responsible for the establishment of persistent human immunodeficiency virus infection is an early regulatory TExpand
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Rapid Viral Escape at an Immunodominant Simian-Human Immunodeficiency Virus Cytotoxic T-Lymphocyte Epitope Exacts a Dramatic Fitness Cost
ABSTRACT Escape from specific T-cell responses contributes to the progression of human immunodeficiency virus type 1 (HIV-1) infection. T-cell escape viral variants are retained following HIV-1Expand
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The MHC class I genes of the rhesus monkey. Different evolutionary histories of MHC class I and II genes in primates.
Homologues of the human HLA-A and -B MHC class I loci have been found in great apes and Old World primates suggesting that these two loci have existed for at least 30 million years. The C locus,Expand
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Attenuation of Simian Immunodeficiency Virus SIVmac239 Infection by Prophylactic Immunization with DNA and Recombinant Adenoviral Vaccine Vectors Expressing Gag
ABSTRACT The prophylactic efficacy of DNA and replication-incompetent adenovirus serotype 5 (Ad5) vaccine vectors expressing simian immunodeficiency virus (SIV) Gag was examined in rhesus macaquesExpand
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