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Automated generation and evaluation of specific MHC binding predictive tools: ARB matrix applications
Average Relative Binding (ARB) matrix methods that directly predict IC50 values allowing combination of searches involving different peptide sizes and alleles into a single global prediction are described.
HIV and SIV CTL escape: implications for vaccine design
These are the important lessons that can be learned from immunodeficiency virus CTL escape that are relevant to vaccine design.
Impact of MHC class I diversity on immune control of immunodeficiency virus replication
Recent studies of T-cell-mediated control of HIV and SIV infection are reviewed, and insight is offered for the design of a successful T- cell-based HIV vaccine in the future.
Mamu-B*08-Positive Macaques Control Simian Immunodeficiency Virus Replication
ABSTRACT Certain major histocompatibility complex (MHC) class I alleles are associated with the control of human immunodeficiency virus and simian immunodeficiency virus (SIV) replication. We have
Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia
It is shown that Tat-specific CD8-positive T-lymphocyte responses select for new viral escape variants during the acute phase of infection, and suggests that responses against viral proteins that are expressed early during the viral life cycle might be attractive targets for HIV vaccine development.
Premature induction of an immunosuppressive regulatory T cell response during acute simian immunodeficiency virus infection.
It is concluded that an early Treg cell response during acute SIV infection may contribute to viral persistence by prematurely limiting the antiviral immune response before infection is cleared.
Rapid Viral Escape at an Immunodominant Simian-Human Immunodeficiency Virus Cytotoxic T-Lymphocyte Epitope Exacts a Dramatic Fitness Cost
This data indicates that reversion to wild type can occur following transmission to MHC-mismatched hosts in the absence of cytotoxic T-lymphocyte (CTL) pressure, due to the reduced fitness of the escape mutant virus.
Reversion of CTL escape–variant immunodeficiency viruses in vivo
It is concluded that escape from CTL responses may exact a cost to viral fitness, and in the absence of selective pressure upon transmission to new hosts, these original escape mutations can be lost.
The MHC class I genes of the rhesus monkey. Different evolutionary histories of MHC class I and II genes in primates.
Comparison of rhesus monkey MHC class I cDNAs to their primate counterparts reveals fundamental differences between M HC class I and class II evolution in primates.
HIV vaccine design: insights from live attenuated SIV vaccines
The strategies defining key components of the protective immune response elicited by live attenuated simian immunodeficiency virus vaccines are discussed.