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Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans.
High dietary fat intake leads to insulin resistance in skeletal muscle, and this represents a major risk factor for type 2 diabetes and cardiovascular disease. Mitochondrial dysfunction and oxidativeExpand
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  • Open Access
Physical Activity/Exercise and Type 2 Diabetes
In Brief This is an abridged reprint of a technical review on exercise and type 2 diabetes, which was originally published in the journal Diabetes Care in October 2004. Full text of this article, asExpand
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Physical Activity/Exercise and Type 2 Diabetes
For decades, exercise has been considered a cornerstone of diabetes management, along with diet and medication. However, high-quality evidence on the importance of exercise and fitness in diabetesExpand
  • 751
  • 24
  • Open Access
Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice
The Mouse Metabolic Phenotyping Center (MMPC) Consortium was established to address the need to characterize the growing number of mouse models of metabolic diseases, particularly diabetes andExpand
  • 464
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  • Open Access
Four grams of glucose.
  • D. Wasserman
  • Medicine, Biology
  • American journal of physiology. Endocrinology and…
  • 2009
Four grams of glucose circulates in the blood of a person weighing 70 kg. This glucose is critical for normal function in many cell types. In accordance with the importance of these 4 g of glucose, aExpand
  • 235
  • 15
  • Open Access
Considerations in the design of hyperinsulinemic-euglycemic clamps in the conscious mouse.
Despite increased use of the hyperinsulinemic-euglycemic clamp to study insulin action in mice, the effects of experimental parameters on the results obtained have not been addressed. In our studies,Expand
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  • Open Access
Evidence that carotid bodies play an important role in glucoregulation in vivo.
The carotid bodies are sensitive to glucose in vitro and can be stimulated to cause hyperglycemia in vivo. The aim of this study was to determine if the carotid bodies are involved in basalExpand
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  • 13
  • Open Access
Physical activity/exercise and type 2 diabetes.
For decades, exercise has been considered a cornerstone of diabetes management, along with diet and medication. However, high-quality evidence on the importance of exercise and fitness in diabetesExpand
  • 521
  • 12
  • Open Access
Mice with AS160/TBC1D4-Thr649Ala Knockin Mutation Are Glucose Intolerant with Reduced Insulin Sensitivity and Altered GLUT4 Trafficking
Summary AS160 has emerged as a key player in insulin-mediated glucose transport through controlling GLUT4 trafficking, which is thought to be regulated by insulin-stimulated phosphorylation of sitesExpand
  • 126
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Prevention of obesity and insulin resistance in mice lacking plasminogen activator inhibitor 1.
Increased plasminogen activator inhibitor 1 (PAI-1) has been linked to not only thrombosis and fibrosis but also to obesity and insulin resistance. Increased PAI-1 levels have been presumed to beExpand
  • 358
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  • Open Access