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A Novel Variant, NDM-5, of the New Delhi Metallo-β-Lactamase in a Multidrug-Resistant Escherichia coli ST648 Isolate Recovered from a Patient in the United Kingdom
ABSTRACT A new variant of the New Delhi metallo-enzyme (NDM) carbapenemase was identified in a multidrug-resistant Escherichia coli ST648 isolate recovered from the perineum and throat of a patient
Antimicrobial resistance in community and nosocomial Escherichia coli urinary tract isolates, London 2005 – 2006
TLDR
Resistance to agents commonly used as empirical oral treatments for UTI was extremely high and levels of resistance to trimethoprim and ampicillin render them unsuitable for empirical use.
Multidrug-resistant Acinetobacter baumannii: mechanisms of virulence and resistance.
  • N. Gordon, D. Wareham
  • Medicine, Biology
    International journal of antimicrobial agents
  • 1 March 2010
TLDR
An overview of current knowledge is provided on mechanisms of pathogenesis, the molecular basis of resistance and options for treatment in the absence of novel therapeutic agents on the basis of A. baumannii infection.
AdeABC-mediated efflux and tigecycline MICs for epidemic clones of Acinetobacter baumannii.
TLDR
Differences in expression of adeABC contribute to both inter- and intra-clone variation in tigecycline MICs, which can arise during therapy, mediated by up-regulation of AdeABC.
Carbapenemase-producing Enterobacteriaceae and non-Enterobacteriaceae from animals and the environment: an emerging public health risk of our own making?
TLDR
The ability to limit the rise and spread of carbapenemase producers should serve as a key performance indicator for the success or failure of the efforts that have been called for by international organizations and governments to reduce the impact of antibiotic resistance.
Development and evaluation of a multiplex PCR for eight plasmid-mediated quinolone-resistance determinants.
TLDR
It is confirmed that PMQR prevalence remains low among human Escherichia coli clinical isolates in the UK and an eight-target multiplex PCR assay for the accurate detection ofPMQR genes is developed.
Potent Synergy and Sustained Bactericidal Activity of a Vancomycin-Colistin Combination versus Multidrug-Resistant Strains of Acinetobacter baumannii
TLDR
This study evaluated the effect of colistin combined with vancomycin on 5 previously characterized epidemic strains and 34 MDRAB clinical isolates by using time-kill assay, microdilution, and Etest methods, finding significant synergy.
Whole-genome comparison of two Acinetobacter baumannii isolates from a single patient, where resistance developed during tigecycline therapy.
TLDR
This study demonstrates that significant differences were detectable between two bacterial isolates recovered 1 week apart from the same patient, and reveals the potential of whole-genome sequencing as a tool for elucidating the processes responsible for changes in antibiotic susceptibility profiles.
In-vitro activity of polymyxin B in combination with imipenem, rifampicin and azithromycin versus multidrug resistant strains of Acinetobacter baumannii producing OXA-23 carbapenemases
  • D. Wareham, D. Bean
  • Biology, Medicine
    Annals of Clinical Microbiology and…
  • 21 April 2006
TLDR
In-vitro synergy with polymxyin in combination with imipenem, rifampicin or azithromycin is highly strain and method dependent and use of such combinations should not be used for empirical treatment of these infections in the UK.
A genotypic and phenotypic comparison of type III secretion profiles of Pseudomonas aeruginosa cystic fibrosis and bacteremia isolates.
  • D. Wareham, M. Curtis
  • Biology, Medicine
    International journal of medical microbiology…
  • 2 July 2007
TLDR
Secretion of the ExoU protein was more commonly seen in isolates obtained from blood, suggesting this ability may be important in the development of acute invasive infection.
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