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Roles of CC chemokine receptors (CCRs) on lipopolysaccharide-induced acute lung injury
The aim of the present study was to evaluate the effects of the CC chemokine receptor (CCR) 2b and CCR1 antagonist RS504393 as well as the roles of CCRs on lipopolysaccharide (LPS)-induced acute lungExpand
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Aquaporins as diagnostic and therapeutic targets in cancer: How far we are?
Aquaporins (AQPs) are a family of water channel proteins distributed in various human tissues, responsible for the transport of small solutes such as glycerol, even gas and ions. The expression ofExpand
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Role of epigenetics in lung cancer heterogeneity and clinical implication.
Lung cancer, as a highly heterogeneous disease, can be initiated and progressed through the interaction between permanent genetic mutations and dynamic epigenetic alterations. However, the mediatingExpand
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Potentials of single‐cell biology in identification and validation of disease biomarkers
Single‐cell biology is considered a new approach to identify and validate disease‐specific biomarkers. However, the concern raised by clinicians is how to apply single‐cell measurements for clinicalExpand
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MicroRNA network analysis identifies key microRNAs and genes associated with precancerous lesions of gastric cancer.
To identify potential targets for the early treatment and prevention of gastric cancer, microRNA (miRNA) expression profiles of precancerous lesions of gastric cancer were investigated. The miRNAExpand
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Lung Cancer Heterogeneity and New Strategies for Drug Therapy.
Lung cancer heterogeneity plays an important role in the development of drug resistance. Comprehensive molecular characterizations of lung cancer can describe hereditary and somatic gene changes,Expand
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Detection of single cell heterogeneity in cancer.
Single cell heterogeneity has already been highlighted in cancer classification, diagnosis, and treatment. Recent advanced technologies have gained more ability to reveal the heterogeneity on singleExpand
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Role of CCR2 and IL-8 in acute lung injury: a new mechanism and therapeutic target
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are severe inflammatory lung diseases associated with very high mortality, and are the most common and earliest organExpand
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I148M variant of PNPLA3 increases the susceptibility to non‐alcoholic fatty liver disease caused by obesity and metabolic disorders
The patatin‐like phospholipase 3 (PNPLA3) rs738409 gene polymorphism is an important genetic determinant of non‐alcoholic fatty liver disease (NAFLD). However, the associations between liver fat andExpand
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Variation of lipopolysaccharide-induced acute lung injury in eight strains of mice
Clinical and experimental evidence suggests that genetic variations may play an important role in the development of acute lung injury (ALI). Lipopolysaccharide (LPS)-induced ALI models has beenExpand
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