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Decreased Expression of the ARID1A Gene Is Associated with Poor Prognosis in Primary Gastric Cancer
TLDR
The data suggest that ARID1A may play an important role in gastric cancer and may serve as a valuable prognostic marker and potential target for gene therapy in the treatment of Gastric cancer. Expand
Interleukin-37 Mediates the Antitumor Activity in Hepatocellular Carcinoma: Role for CD57+ NK Cells
TLDR
In vitro chemotaxis analysis and in vivo mouse model experiments revealed that overexpression IL-37 in HCC cells significantly delayed tumor growth and recruited more NK cells into tumors tissues, suggesting thatIL-37 might play an important role for the prognosis of HCC patients via regulating innate immune-action. Expand
Cerebral ischemia and Alzheimer's disease: the expression of amyloid-beta and apolipoprotein E in human hippocampus.
TLDR
The observation that the accumulation of both Abeta1-40 and beta1-42 were increased dramatically and consistently after cerebral ischemia provides a basis for establishing therapeutic strategies aimed at preventing ischemic insults and subsequent neurodegeneration in AD. Expand
Nociception-induced spatial and temporal plasticity of synaptic connection and function in the hippocampal formation of rats: a multi-electrode array recording
TLDR
The initial pharmacological investigation showed that AMPA/KA glutamate receptors might play more important roles in mediation of pain-associated spatiotemporal plasticity than NMDA receptors. Expand
Dysregulation of p53-RBM25-mediated circAMOTL1L biogenesis contributes to prostate cancer progression through the circAMOTL1L-miR-193a-5p-Pcdha pathway
TLDR
These findings have linked p53/RBM25-mediated circAMOTL1L-miR-193a-5p-Pcdha8 regulatory axis to EMT in metastatic progression of PCa, and Targeting this newly identified regulatory axis provides a potential therapeutic strategy for aggressive PCa. Expand
Annexin A3 promotes tumorigenesis and resistance to chemotherapy in hepatocellular carcinoma
TLDR
The findings reveal that ANXA3 might play an important role in HCC progression and chemoresistance, and could serve as a novel prognostic marker and therapeutic target for HCC. Expand
IL-17A Promotes Immune Cell Recruitment in Human Esophageal Cancers and the Infiltrating Dendritic Cells Represent a Positive Prognostic Marker for Patient Survival
  • L. Lu, K. Pan, +10 authors J. Xia
  • Biology, Medicine
  • Journal of immunotherapy
  • 1 October 2013
TLDR
With the analyses of 181 ESCC patients, a correlation of higher number of tumor-infiltrating CD1a+ DCs with significantly improved overall survival of patients with ESCC is found. Expand
Validity of plasma macrophage migration inhibitory factor for diagnosis and prognosis of hepatocellular carcinoma
TLDR
With determined cutpoints, plasma MIF levels demonstrated a significant association with overall survival (OS) and disease‐free survival (DFS) of HCC patients even in patients with normal serum AFP levels and Tumor Node Metastasis stage I. Expand
Expression and prognostic role of ubiquitination factor E4B in primary hepatocellular carcinoma
TLDR
The findings suggested that UBE4B might have an oncogenic role in human primary HCC, and that it could be used as a prognostic marker (as well as a potential molecular target) for the treatment of HCC. Expand
Decreased Expression of the GATA3 Gene Is Associated with Poor Prognosis in Primary Gastric Adenocarcinoma
TLDR
It is suggested that Gata3 plays an important role in tumor progression and that reduced GATA3 expression independently predicts an unfavorable prognosis in primary gastric adenocarcinoma patients. Expand
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