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A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine.
  • D. Wallace
  • Biology, Medicine
  • Annual review of genetics
  • 14 November 2005
The mitochondria provide a direct link between the authors' environment and their genes and the mtDNA variants that permitted their forbears to energetically adapt to their ancestral homes are influencing their health today. Expand
Mitochondrial diseases in man and mouse.
The essential role of mitochondrial oxidative phosphorylation in cellular energy production, the generation of reactive oxygen species, and the initiation of apoptosis has suggested a number of novel mechanisms for mitochondrial pathology. Expand
Classification of European mtDNAs from an analysis of three European populations.
The conclusion that most haplogroups observed in Europe are Caucasoid-specific, and that at least some of them occur at varying frequencies in different Caucasoid populations, is supported. Expand
The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore
It is shown that mitochondria lacking ANT could still be induced to undergo permeability transition, resulting in release of cytochrome c. Expand
Natural selection shaped regional mtDNA variation in humans
It is concluded that selection may have played a role in shaping human regional mtDNA variation and that one of the selective influences was climate. Expand
Asian affinities and continental radiation of the four founding Native American mtDNAs.
Observations suggest that the process of tribalization began early in the history of the Amerinds, with relatively little intertribal genetic exchange occurring subsequently. Expand
Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy.
This finding demonstrated that a nucleotide change in a mitochondrial DNA energy production gene can result in a neurological disease. Expand
Extension of Murine Life Span by Overexpression of Catalase Targeted to Mitochondria
Transgenic mice that overexpress human catalase localized to the peroxisome, the nucleus, or mitochondria were generated and the importance of mitochondria as a source of radicals was reinforced. Expand
A back migration from Asia to sub-Saharan Africa is supported by high-resolution analysis of human Y-chromosome haplotypes.
Phylogeographic analyses suggest that a large component of the present Khoisan gene pool is eastern African in origin and that Asia was the source of a back migration to sub-Saharan Africa. Expand
Effects of Purifying and Adaptive Selection on Regional Variation in Human mtDNA
A phylogenetic analysis of 1125 global human mitochondrial DNA sequences permitted positioning of all nucleotide substitutions according to their order of occurrence, and particularly highly conserved amino acid substitutions were found at the roots of multiple mtDNA lineages from higher latitudes. Expand