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Atherosclerosis and calcium signalling in endothelial cells.
CRH-induced electrical activity and calcium signalling in pituitary corticotrophs.
It is found that a CRH-induced inhibition of the inwardly rectifying K+ current increases the model action potential firing frequency, [Ca2+]i transients and membrane excitability, and the model exhibits experimentally observed bursting behaviour.
A mathematical model for analysis of the cell cycle in cell lines derived from human tumors
A mathematical model has been used to predict the response of cells to mitotic arrest, and the results are compared to experimental data using a human melanoma cell line exposed to the anticancer drug paclitaxel.
Tissue-specific changes in angiotensin II receptors in streptozotocin-diabetic rats.
There are major changes in AT receptors in the STZ-diabetic rat that are tissue-specific and time-dependent, and plasma angiotensinogen and renin secretion change in directions that result in the maintenance of plasma renin activity and aldosterone concentration.
A Hodgkin-Huxley model exhibiting bursting oscillations
Bifurcation analysis and the use of null-surfaces facilitate a geometric interpretation of the model bursting modes and action potential generation, respectively and mode transitions and similar modes of bursting in other Hodgkin-Huxley models are investigated.
On a functional equation model of transient cell growth.
A cell-growth model with applications to modelling the size distribution of diatoms is examined. The analytic solution to the model without dispersion is found and is shown to display periodic
Macro-scale phenomena of arterial coupled cells: a massively parallel simulation
Results show that the heterocellular calcium (Ca2+) coupling between ECs and SMCs is important in eliciting a rapid response when the vessel segment is stimulated by the agonist gradient.
The steady-states of a multi-compartment, age–size distribution model of cell-growth
A model of cell-growth, describing the evolution of the age–size distribution of cells in different phases of cell-growth, is studied. The model is based on that used in several papers by Basse et