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Atherosclerosis and calcium signalling in endothelial cells.
The link between atherosclerosis and regions of disturbed flow and low wall shear stress is now firmly established, but the causal mechanisms underlying the link are not yet understood. It is nowExpand
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CRH-induced electrical activity and calcium signalling in pituitary corticotrophs.
Pituitary corticotroph cells generate repetitive action potentials and associated Ca2+ transients in response to the agonist corticotropin releasing hormone (CRH). There is indirect evidenceExpand
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A mathematical model for analysis of the cell cycle in cell lines derived from human tumors
Abstract.The growth of human cancers is characterised by long and variable cell cycle times that are controlled by stochastic events prior to DNA replication and cell division. Treatment withExpand
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Tissue-specific changes in angiotensin II receptors in streptozotocin-diabetic rats.
While there have been reports on changes in the renin-angiotensin system and angiotensin II (AT) receptors in diabetes, there is no agreement on the nature of these changes. This study hasExpand
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A Hodgkin-Huxley model exhibiting bursting oscillations
We investigate bursting behaviour generated in an electrophysiological model of pituitary corticotrophs. The active and silent phases of this mode of bursting are generated by moving between twoExpand
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Concentration of blood-borne agonists at the endothelium
The delivery of endothelial ligands and macromolecules, such as lipoproteins, from the circulation to the arterial wall is of central importance in modulating endothelial cell function and physiologyExpand
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The role of endothelial calcium and nitric oxide in the localisation of atherosclerosis.
A mathematical model of endothelial cell calcium signalling and nitric oxide synthesis under flow conditions is presented. The model is coupled to two important environmental stimuli for endothelialExpand
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Modelling the flow cytometric data obtained from unperturbed human tumour cell lines: Parameter fitting and comparison
aMax Planck Institute for Mathematics in the Sciences, Inselstrasse 22-26, 04103 Leipzig, Germany bAuckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, University ofExpand
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Macro-scale phenomena of arterial coupled cells: a massively parallel simulation
Impaired mass transfer characteristics of blood-borne vasoactive species such as adenosine triphosphate in regions such as an arterial bifurcation have been hypothesized as a prospective mechanism inExpand
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The steady-states of a multi-compartment, age–size distribution model of cell-growth
A model of cell-growth, describing the evolution of the age–size distribution of cells in different phases of cell-growth, is studied. The model is based on that used in several papers by Basse etExpand
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