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Prevalence and Pattern of Lumbar Magnetic Resonance Imaging Changes in a Population Study of One Thousand Forty-Three Individuals
TLDR
There was a positive correlation between the DDD score and low back pain and in a population setting, there is a significant association of LDD on MRI with back pain.
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Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia
TLDR
The CREAM consortium conducted genome-wide meta-analyses, which identified 16 new loci for refractive error in individuals of European ancestry and 8 were shared with Asians, and identified 8 additional associated loci.
View on Nature
Lumbar disc degeneration is linked to a carbohydrate sulfotransferase 3 variant.
TLDR
The findings from linkage and association studies are reported, providing new insights into the etiology of LDD, implicating an interplay between genetic risk factors and miRNA.
View on PubMed
Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia
TLDR
The CREAM consortium conducted genome-wide meta-analyses, which identified 16 new loci for refractive error in individuals of European ancestry and 8 were shared with Asians, and identified 8 additional associated loci.
View on Nature
Association of the asporin D14 allele with lumbar-disc degeneration in Asians.
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Association of High Myopia with Crystallin Beta A4 (CRYBA4) Gene Polymorphisms in the Linkage-Identified MYP6 Locus
TLDR
A novel susceptibility gene (CRYBA4) was discovered for high myopia and signified the potential importance of appropriate gene prioritization in candidate selection.
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Association between promoter -1607 polymorphism of MMP1 and Lumbar Disc Disease in Southern Chinese
TLDR
It is demonstrated that individuals with the presence of D allele for the -1607 promoter polymorphism of MMP1 are about 1.5 times more susceptible to develop DDD when compared with those having G allele only.
View on Springer
Intervertebral disc degeneration: new insights based on "skipped" level disc pathology.
TLDR
The study challenges the paradigm that age and biomechanical factors are the key factors associated with the development of disc degeneration and finds novel findings of SLDD patterns, which provide further awareness of and support for the notion that additional etiologic factors may play a role in the Development of Disc degeneration.
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(ii) Family-based linkage and case control association studies
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UPDG: Utilities package for data analysis of Pooled DNA GWAS
TLDR
UPDG provides a free, simple and platform-independent one-stop service to scientists working on pooled DNA GWAS data analysis, but with less advanced programming knowledge, and is especially useful for users with some computer knowledge, but without a sophisticated programming background.
View on Springer
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