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Generic Indicators for Loss of Resilience Before a Tipping Point Leading to Population Collapse
Predicting Catastrophic Collapse It is very difficult to predict the behavior of complex systems near tipping points, where a small change in conditions can lead to a large shift in the state of theExpand
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Alba shapes the archaeal genome using a delicate balance of bridging and stiffening the DNA
Architectural proteins have an important role in shaping the genome and act as global regulators of gene expression. How these proteins jointly modulate genome plasticity is largely unknown. InExpand
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The role of the cytoskeleton in sensing changes in gravity by nonspecialized cells
A large body of evidence indicates that single cells in vitro respond to changes in gravity, and that this response might play an important role for physiological changes at the organism level duringExpand
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Identification of phagocytosis regulators using magnetic genome-wide CRISPR screens
Phagocytosis is required for a broad range of physiological functions, from pathogen defense to tissue homeostasis, but the mechanisms required for phagocytosis of diverse substrates remainExpand
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Nanomechanics of Extracellular Vesicles Reveals Vesiculation Pathways.
Extracellular vesicles (EVs) are emerging as important mediators of cell-cell communication as well as potential disease biomarkers and drug delivery vehicles. However, the mechanical properties ofExpand
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Competition between Bending and Internal Pressure Governs the Mechanics of Fluid Nanovesicles
Nanovesicles (∼100 nm) are ubiquitous in cell biology and an important vector for drug delivery. Mechanical properties of vesicles are known to influence cellular uptake, but the mechanism by whichExpand
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The fluid membrane determines mechanics of erythrocyte extracellular vesicles and is softened in hereditary spherocytosis
Extracellular vesicles (EVs) are widely studied regarding their role in cell-to-cell communication and disease, as well as for applications as biomarkers or drug delivery vehicles. EVs containExpand
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Controlled tip wear on high roughness surfaces yields gradual broadening and rounding of cantilever tips
Tip size in atomic force microscopy (AFM) has a major impact on the resolution of images and on the results of nanoindentation experiments. Tip wear is therefore a key limitation in the applicationExpand
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Multilamellar nanovesicles show distinct mechanical properties depending on their degree of lamellarity.
Small multilamellar vesicles may have benefits over unilamellar vesicles for drug delivery, such as an increased volume for hydrophobic drugs. In addition, their altered mechanical properties mightExpand
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Superresolved and reference-free microparticle traction force microscopy (MP-TFM) reveals the complexity of the mechanical interaction in phagocytosis
Force exertion is an integral part of cellular behavior. Traction force microscopy (TFM) has been instrumental for studying such forces, providing both spatial and directional force measurements atExpand
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