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Psychological sequelae of the September 11 terrorist attacks in New York City.
TLDR
There was a substantial burden of acute PTSD and depression in Manhattan after the September 11 attacks, and experiences involving exposure to the attacks were predictors of current PTSD, and losses as a result of the events were predictions of current depression.
Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene
TLDR
The CKR5Δ32 deletion may act as a recessive restriction gene against HIV-1 infection and may exert a dominant phenotype of delaying progression to AIDS among infected individuals.
Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS
TLDR
The strongest synergistic effect of these loci was on progression to depletion of CD4+ T cells, which suggests that a protective response of NK cells involving KIR3DS1 and its HLA class I ligands begins soon after HIV-1 infection.
HLA and HIV-1: heterozygote advantage and B*35-Cw*04 disadvantage.
TLDR
The extended survival of 28 to 40 percent of HIV-1-infected Caucasian patients who avoided AIDS for ten or more years can be attributed to their being fully heterozygous at HLA class I loci, to their lacking the AIDS-associated alleles B*35 and Cw*04, or to both.
The epidemiology of post-traumatic stress disorder after disasters.
TLDR
The purpose in this review is to contribute to this overall goal by comprehensively and systematically assessing the epidemiologic evidence about PTSD after disasters.
HLA and NK Cell Inhibitory Receptor Genes in Resolving Hepatitis C Virus Infection
TLDR
The data strongly suggest that inhibitory NK cell interactions are important in determining antiviral immunity and that diminished inhibitory responses confer protection against HCV.
Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression. Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter
TLDR
Genetic association analysis of five acquired immunodeficiency syndrome (AIDS) cohorts revealed that although CCR2-64I exerts no influence on the incidence of HIV- 1 infection, HIV-1-infected individuals carrying the C CR2- 64I allele progressed to AIDS 2 to 4 years later than individuals homozygous for the common allele.
Mortality, CD4 cell count decline, and depressive symptoms among HIV-seropositive women: longitudinal analysis from the HIV Epidemiology Research Study.
TLDR
The results indicate that depressive symptoms among women with HIV are associated with HIV disease progression, controlling for clinical, substance use, and sociodemographic characteristics.
The natural history of hepatitis C virus infection: host, viral, and environmental factors.
TLDR
The results indicate that although HCV infection can be self-limited or associated with ESLD, the majority of adults have persistent viremia without clinically demonstrable liver disease.
Genetic restriction of AIDS pathogenesis by an SDF-1 chemokine gene variant. ALIVE Study, Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia
TLDR
The recessive protective effect of SDF1-3'A was increasingly pronounced in individuals infected with HIV-1 for longer periods, was twice as strong as the dominant genetic restriction of AIDS conferred by CCR5 and CCR2 chemokine receptor variants in these populations, and was complementary with these mutations in delaying the onset of AIDS.
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