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Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor.
FoxP3 is a key transcription factor for the development and function of natural CD4(+) regulatory T cells (Treg cells). Here we show that human FoxP3(+)CD4(+) T cells were composed of threeExpand
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An official American Thoracic Society/European Respiratory Society statement: Update of the international multidisciplinary classification of the idiopathic interstitial pneumonias.
BACKGROUND In 2002 the American Thoracic Society/European Respiratory Society (ATS/ERS) classification of idiopathic interstitial pneumonias (IIPs) defined seven specific entities, and providedExpand
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Combined pulmonary fibrosis and emphysema: a distinct underrecognised entity
The syndrome resulting from combined pulmonary fibrosis and emphysema has not been comprehensively described. The current authors conducted a retrospective study of 61 patients with both emphysema ofExpand
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Pulmonary hypertension associated with sarcoidosis: mechanisms, haemodynamics and prognosis
Background: Pulmonary hypertension (PH) is a rare complication of sarcoidosis, although it is not uncommon in advanced disease. Methods: A retrospective series of 22 sarcoidosis patients (16 men) ofExpand
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The immune paradox of sarcoidosis and regulatory T cells
Sarcoidosis is characterized by extensive local inflammation (granuloma, cytokine secretion) associated with anergy (poor response to antigens in vitro and in vivo). We postulated that thisExpand
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Tuberculosis in HIV-infected patients: a comprehensive review.
The incidence of tuberculosis (TB) is currently increasing in HIV-infected patients living in Africa and Asia, where TB endemicity is high, reflecting the susceptibility of this group of patients toExpand
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Combined pulmonary fibrosis and emphysema syndrome in connective tissue disease.
OBJECTIVE Connective tissue diseases (CTDs) are associated with several interstitial lung diseases. The aim of this study was to describe the recently individualized syndrome of combined pulmonaryExpand
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Sarcoidosis
Sarcoidosis is a systemic disease of unknown cause that is characterised by the formation of immune granulomas in various organs, mainly the lungs and the lymphatic system. Studies show thatExpand
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Six-minute-walk test in idiopathic pulmonary fibrosis: test validation and minimal clinically important difference.
RATIONALE The 6-minute-walk test (6MWT) is a practical and clinically meaningful measure of exercise tolerance with favorable performance characteristics in various cardiac and pulmonary diseases.Expand
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Forced vital capacity in patients with idiopathic pulmonary fibrosis: test properties and minimal clinically important difference.
RATIONALE Forced vital capacity (FVC) is an established measure of pulmonary function in idiopathic pulmonary fibrosis (IPF). Evidence regarding its measurement properties and minimal clinicallyExpand
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